成都地区汉族群体凝血因子A和B亚单位的遗传多态性研究  

GENETIC POLYMORPHISMS OF FXⅢA AND-B SUBUNITS IN THE HAN POPULATION IN CHENGDU,CHINA

作　　者：张林[1] 苟清[1] 侯一平[1] 吴梅筠[1] 

机构地区：[1]华西医科大学法医系

出　　处：《中华医学遗传学杂志》1994年第5期267-269,共3页Chinese Journal of Medical Genetics

基　　金：国家自然科学基金;纽约中华医学基金

摘　　要：应用聚丙烯酰胺凝胶等电聚焦酶免疫检测技术，调查了成都地区汉族群体凝血因子ＸⅢＡ和ＸⅢＢ的遗传多态性。等位基因频率为：Ｆ　Ａ＊１＝０．８７１９，Ｆ　Ａ＊２＝０．１２４０，Ｆ　Ａ＊３＝０．００４１；Ｆ　Ｂ＊１＝０．２７２７，Ｆ　Ｂ＊２＝０．０１６５，Ｆ　Ｂ＊３＝０．７１０７，Ｆ　表现型频率分布符合Ｈａｒｄｙ－Ｗｅｉｎｂｅｒｇ平衡定律。与国外其他群体的资料相比较，中国人Ｆ　Ａ＊１和Ｆ　Ｂ＊３等位基因频率相对较高。Coagulation factor XⅢ A and XⅢ B polymorphisms in a random population sample from Chengdu in southwest China(n=121)were studied using isoelectric focusing in polyacrylamide gels followed by immunoblotting with enzyme immunoassay, The allele frequencies were: F XⅢ A *1=0.8719,F XⅢ A * 2=0.1240, FXⅢ*A 3=0.0041;FXⅢB*1=0.2727,FXⅢB*2=0.0165,FXⅢB*3=0.7107.Comparing these allele frequencies with those reported in other populations, we found that the allele frequencies of FXⅢ A *1 and F XⅢ B * 3 in the Chinese population were higher.

关 键 词：凝血因子 多态性 等电聚焦 酶免疫检测 

分 类 号：R392.2[医药卫生—免疫学] Q986[医药卫生—基础医学]