长春地区汉族人群c-ab1等位基因的遗传多态性  

ALLELE TYPES AND GENETIC ANALYSIS OF c-ab1 GENE IN A HAN CHINESE POPULATION OF CHANGCHUN

作　　者：姚程[1] 夏海龙[1] 易永林[1] 徐德启[2] 

机构地区：[1]白求恩医科大学第一临床医院血液科,长春130021 [2]卫生部长春生物制品研究所分子生物学研究室

出　　处：《中华医学遗传学杂志》1994年第6期337-338,共2页Chinese Journal of Medical Genetics

摘　　要：以完整的v-ab1癌基因为探针,用DNA印迹杂交方法在长春地区汉族人群中随机检测到c-ab1癌基因位点存在限制性片段长度多态性(RFLP),其原因是c-ab1癌基因位点存在a、b、c3个等位基因。a等位基因频率为94.7%;b等位基因频率为1.9%;c等位基因频率为3.4%。与Caucasian人群c-ab1 RFLP比较,a、b等位基因相同,基因频率相似,而在中国人群中新发现一个c等位基因。A restriction fragment length polymorphism (RFLP) at the human c-abl locus has been detected in a Han population of Changchun by Southern blotting Using ^(32)P-labeled v-abl probe. This polymorphism is generated by the existence of three alleles, a, b and c, which are frequencies of 94.7%, 1.9% and 3.4%, repectively. The inheritance of the three alleles follows the Mendelian pattern. In comparison with c-abl RFLP in Caucasian population, both alleles a and b showed no difference and their frequencies were similar. A new allele c was discovered in Chinese population.

关 键 词：致癌基因 C-ab1 基因 多态性 DNA 印迹 

分 类 号：R392.2[医药卫生—免疫学] Q986[医药卫生—基础医学]