检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
机构地区:[1]温州医学院附属第一医院骨科手外组,浙江温州325000 [2]上海第九人民医院骨科研究所
出 处:《中国实验诊断学》2005年第3期445-447,共3页Chinese Journal of Laboratory Diagnosis
摘 要:目的对大鼠同种异体肢体移植术后急性排斥反应阶段外周血T淋巴亚群的动态监测,以了解其变化与受者免疫状态之间的关系。方法在异体肢体移植术后1、3、5、7、9d,运用流式细胞仪测试外周血T淋巴细胞亚群动态变化。结果术后1d,外周血CD4+和CD8+细胞均明显增加,CD4+/CD8+比值与术前CD4+/CD8+比值差异不显著(P>0·05),术后3d,CD4+增加显著,CD8+增加不明显,CD4+/CD8+比值明显升高,与术前和术后1d比较差异(P<0·01),术后5~9d,CD4+/CD8+比值仍维持较高水平。结论外周血CD4+/CD8+细胞比值系列变化可用于预测肢体移植急性排斥反应。Objective To investigate the value of T lymphocyte subsets during the acute rejection of hindlimb allograft in rats. Methods T lymphocyte subsets of peripheral blood were consecutively detected by using T-lymphocyte subsets monoclonal antibody-OKT at 1?3?5?7?9 d after hindlinm allogrft. Results The value of CD4^+ and CD8^+ increase obviously 1 d postoperation, however, the ratio of CD4^+/CD8^+ has no difference(P>0.05). the ratio of CD4^+/CD8^+ increses obviously in 3 d and has significance compared to ratio in 1 d. the ratio still keep a higher level during 5 d-9 d after operation. Conclusion The ratio of CD4^+/CD8^+ can predict and monitor the acute rejection of limb allograft.
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.63