脑脊液中肿瘤坏死因子及白细胞介素-6的检测对颅内感染鉴别诊断的临床意义  

Clinical significance of the detection of tumor necrosis factor and interleukin-6 in cerebrospinal fluid in children for the differentiating diagnosis of acute intracranial infection

作　　者：张伟忠[1] 赵萍[1] 严文康[1] 郭秀东[1] 

机构地区：[1]广东省惠州市中心人民医院儿科,516001

出　　处：《河北医药》2005年第6期407-408,共2页Hebei Medical Journal

摘　　要：目的探讨脑脊液中肿瘤坏死因子(TNFα)、白细胞介素6(IL6)的含量与颅内感染的性质及病情的关系。方法采用ELISA法测定颅内感染患儿54例和对照组20例正常儿脑脊液中TNFα与IL6水平。结果颅内感染患儿脑脊液中TNFα、IL6水平明显高于对照组,尤以化脓性脑膜炎中含量增高更为明显;脑脊液中TNFα、IL6水平与其白细胞计数、蛋白质含量之间相关性分析差异未见显著性。结论TNFα、IL6参与了颅内感染的病理、生理过程,脑脊液中TNFα、IL6含量的测定对脑炎的鉴别诊断、病情严重程度的判断有临床意义。Objective To investigate the relationship between the characteristic and condition of intracranial infection and the levels of interleukin-6 and tumor necrosis factor in cerebrospinal fluid.Methods The levels of TNF-α and interleukin-6 in cerebrospinal fluid were detect ed by ELISA method in 54 children who were admitted with acute intracranial infection,the other 20 normal children were served as control group.Results The cerebrospinal fluid levels of IL-6 and TNF-α in patients with acute intracranial infection were obviously higher than those of control group,especially in those children who were admitted with purulent meningitis,however,there was no difference between the levels of IL-6,TNF-α and the leucocytes counts,content of protein.Conclusion TNF-α and IL-6 are involved in the course of pathology and physiology of intracranical infection,the detection of levels of IL-6 and TNF-α in cerebrospinal fluid are of important significance for the differentiating diagnosis and the evaluation of disease severity degree.

关 键 词：颅内感染 临床意义 鉴别诊断 白细胞介素-6 脑脊液 肿瘤坏死因子(TNF-α) 检测 ELISA法 化脓性脑膜炎 IL-6含量 病情严重程度 白细胞计数 相关性分析 蛋白质含量 生理过程 对照组 水平 正常儿 显著性 患儿 测定 

分 类 号：R651.11[医药卫生—外科学] R541.4[医药卫生—临床医学]