胶原蛋白硫代改性方法的研究  

Study on the Thiomodification of the Collagen

作　　者：周磊[1] 陈敏[1] 程海明[1] 王睿[1] 廖隆理[1] 李志强[1] 

机构地区：[1]皮革化学与工程教育部重点实验室,四川大学四川成都610065

出　　处：《皮革科学与工程》2005年第3期12-15,19,共5页Leather Science and Engineering

基　　金：国家863项目"3D-SC组织工程材料的研制项目"(2001AA326090)子项目

摘　　要：采用γ-硫代丁内酯对胶原蛋白进行了硫代交联改性。系统研究了不同酸溶液、不同咪唑用量和不同的改性温度对胶原蛋白的相对分子质量和粒径大小及分布的影响。实验结果表明,乳酸溶液中不能发生的交联改性,能够在醋酸溶液中很好的进行,在中性pH条件范围内,咪唑的用量对胶原蛋白改性的影响最大,温度的影响很小。In this paper,γ-thiobutyrolactone used in modification of the collagen was adopted. The influencing factors on physical and chemical character of collagen, different acid environment, different pH adjusted by different amount of imidazole, and different modification temperature were studied. At the same time, the molecular weight of collagen, diameter and distribution of particles were discussed. The experimental results showed that crosslink action was able to generate in acetic acid solution rather than in lactic acid solution. In the range of neutral pH, the effect of the imidazole amount on the modification of collagen was most remarkable, reversely, the effect of temperature was little.

关 键 词：胶原蛋白 γ-硫代丁内酯 硫代改性 

分 类 号：TS512[轻工技术与工程—皮革化学与工程]