原发性肾病综合征患者血清载脂蛋白的变化  

Serum apelipeprotein abnonuakties in patients withidiopathic nephrotic syndrome

作　　者：张桦[1] 黄文聪[1] 唐世聪[1] 董秀清[1] 张仕光[1] 余学清[1] 许乃贵[1] 何柏林[1] 

机构地区：[1]广州中山医科大学肾脏病研究所,广东省珠海市医疗中心内科

出　　处：《中华医学杂志》1994年第9期542-544,共3页National Medical Journal of China

摘　　要：对４５例原发性肾病综合征（ＮＳ）患者的血脂和载脂蛋白（ａｐｏ）进行检测，发现ＮＳ患者具有广泛的脂代谢异常，ａｐｏＡＩ（ｌｌｌ２±ｌ８７ｍｇ／Ｌ）、ＡＩＩ（２６６±７７ｍｇ／Ｌ）浓度降低，ａｐｏＢｆ１７ｌ０±４４４ｍｇ／Ｌ）、ＣＩＩ（９７±４２ｍｇ／Ｌ）、ＣＩＩＩ（２４７±９６ｍｇ／Ｌ）浓度显著升高，ａｐｏＡｌ／ａｐｏＢ比值（０．７０±０．２４）显著降低。而在缓解期，一部分患者血脂、脂蛋白浓度正常，但ａｐｏ仍有明显异常。结果提示：ＮＳ患者发生冠心病的危险性增加，而ａｐｏ是较血脂更为敏感的ＮＳ心血管并发症的预测指标。e measured serum lipid and apolipoprotein(apo) levels in 45 patients with noimal renal functionat different stages of idiopathic nephrotic syndrome(NS). Wide abnonnalities of lipid metabolism werefound. The characteristic disorder of serum apos in NSwas a decrease in apoAl and AII and a significant in-crease in apoB, CII, and CIII. Consequently, the ratioof apoAI to apoB was significantly decreased. Somepatients with NS in remission had nonnal serum lipidconeentrations, but abnonnalities of serum apos werestill observed. It is suggested that the nephrotic pa-tients may be at increasing risk for coronary heart disease (CHD), and that apos may be more sensitivepredicators of CHD than lipids.

关 键 词：高血脂病 肾病综合征 载脂蛋白 

分 类 号：R692[医药卫生—泌尿科学]