人重组粒细胞集落刺激因子对急性心肌梗死患者心功能恢复的疗效观察  

The Study of Efficacy on Improvement of Heart Function of Patients with Acute Myocardial Infarction Treated with rhG-CSF

作　　者：庄俊合 邓志刚[2] 陆东风[2] 林伟[2] 邬恒夫[2] 

机构地区：[1]普宁市人民医院心内科,普宁515300 [2]广州医学院第二附属医院,广州510260

出　　处：《血栓与止血学》2005年第3期109-111,共3页Chinese Journal of Thrombosis and Hemostasis

基　　金：广州市科技局立项课题(2004Z3-E0391)

摘　　要：目的探讨人重组粒细胞集落刺激因子(rhG-CSF)瑞血新治疗急性心肌梗死(AMI)对患者心功能恢复的作用。方法除药物或介入治疗外,治疗组AMI病人在心梗发生48h后连续5d每天皮下注射瑞血新约5μg/kg。AMI后5d内和3个月后,分别行PET检测左心室射血分数(LVEF)、心梗面积和存活心肌,评价心功能的变化,比较实验组和对照组心功能的变化来评价rhG-CSF对AMI患者心功能恢复的疗效。结果AMI后3个月,两组LVEF较前无明显提高;梗死面积均较前明显缩小;rhG-CSF组存活心肌明显为少,对照组亦减少但差异无显著性。结论暂未能认为rhG-CSF能改善AMI患者心功能。Objective To evaluate the efficacy of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on patients with acute myocardial infarction (AMI) treated with rhG-CSF. Methods In addition to traditional treatment, including medicine or percutaneous coronary intervention (PCI), was given, the patients with AMI in therapy group were injected subcutaneously daily with 5 μg/(kg·d) recombinant human G-CSF for 5 days in 48 hours after onset of AMI while those in control were injected nothing as a control. The examination of all patients'heart function was performed with PET measuring left ventricular ejection fraction (LVEF), infarcted size and living myocardium in 5 days and 3 months respectively after onset of AMI, and the efficacy of rhG-CSF was evaluated by comparison of improvement of hear function between two groups. Results After 3 months of AMI, in both groups the LVEF was slightly increased (P>0. 05) while infracted size was dramatically decreased (P<0.05) , living myocardium in rhG-CSF group is greatly decreased (P<0.05) and that in control slightly decreased (P>0.05). Conclusion The current strdy still cant demonstrate that rhG-CSF is effective on improving heart function of AMI patients.

关 键 词：粒细胞集落刺激因子 急性心肌梗死 骨髓干细胞 正电子发射体层显像 

分 类 号：R542.2[医药卫生—心血管疾病]