汉族与维族Rh血型的血清学比较研究  

Studied on Rh blood group in Han nationality comparison with in Uigrus by blood group and serology method

作　　者：兰炯采[1] 周华友[1] 庞桂芝 白旭华 王晓珠 蔡玲君 张印则[1] 杨全科 

机构地区：[1]第一军医大学南方医院,广州510515 [2]新乡血站,新乡453000 [3]新疆建设兵团血站,乌鲁木齐830002 [4]秦皇岛血站,秦皇岛066001 [5]云南肿瘤医院血库,昆明650118 [6]长垣科隆技术开发有限公司,新乡453400

出　　处：《中国免疫学杂志》2005年第6期441-443,共3页Chinese Journal of Immunology

基　　金：本课题受国家自然科学基金资助(30271208)

摘　　要：目的:采用血型血清学技术比较汉族与维族Rh血型的特点并分析其意义。方法:用抗-D、抗-C、抗-E、抗-e单克隆和多克隆抗血清常规检测Rh抗原,盐水法阴性样本用间接抗球蛋白试验确认其为Rh抗原血清学阴性,用吸收放散试验检出Del型样本。结果:228例随机非血缘关系汉族RhD(-)样本中,以ccee表型多见,共130例(57.02%),其次是Ccee,68例(29.82%),第三是CCee型,11例(4.82%),未检测到CCEe型和CcEE。72例随机非血缘关系新疆维吾尔族RhD(-)样本中仅检测到ccee、Ceee和CCee三种表型,也是以ccee表型(88.89%)多见,而且比例远远高于汉族人,二者相比有极显著性差异(X2=24.33,P<0.005)。Ccee表型(5.56%)和汉族人相比也有极显著性差异(X2=17.67,P<0.005)。CCee表型和汉族人的相比无差异(X2=0.0004,P>0.05)。228例随机非血缘关系汉族RhD(-)样本中检出42例Del型(18.42%),而72例随机非血缘关系维吾尔族RhD(-)样本未检测到Dd型。6例弱D样本均显示阳性结果,但凝集反应弱,3例“Du型”样本有两例可归为弱D型,一例用盐水法凝集反应为阴性,用间接抗球蛋白试验弱阳性,属于极弱D型。结论:新疆维吾尔族人Rh血型既有东方人的特点,也有白种人的特点,是一个特殊的中华民族。Objective:Studied on Rh blood group in Han nationality comparison with in Uigrus by blood group and serology method, and its significance was discussed.Methods:Rh antigens were detected with monoclonal and multiclonal D,C,c,E,e antibodies routinely. Negative results with routine serology were confirmed with IAT and Del types were detected with absorption/elution test.Results:The phenotypes out of 228 cases of unrelative Hans with RhD(-) were 130 ccee(57.02%),68 Ccee(29.82%) and 11 CCee(4.82%),without CCEe and CcEE phenotypes.The ccee(88.89%),Ccee(5.56%) and CCee(5.56%) phenotypes could be detected only out of 72 cases of Uigurs with RhD (-) in Xinjiang, China, and the ratio of Uigurs in ccee and Ccee phenotypes was higher than that of Hans(P<0.005), but the ratio of CCee didn't posses statistical discrepancy(P>0.05),compared to that of Hans.42 cases of the Del types(18.42%) were detected out of 228 unrelative Hans with RhD(-),however, none of the Del types was obtained out of 72 unrelative Uigurs. 6 cases of weak D belonged to RhD positive with weak agglutination,and 3 cases of D'types were classified to weak D,but the other D'type showed negative with saline agglutination test and weak positive with IAT(belong to low graded weak D).Conclusion: Rh bood group of Uigurs on Xinjiang posses Oriental and Caucasian characteristics,which is a special Chinese nationality.

关 键 词：RH血型 血型血清学 汉族 维吾尔族 

分 类 号：R457.11[医药卫生—治疗学]