祖籍湖北汉族鼻咽癌患者与HLA抗原相关的研究  

Study on correlation between nasopharyngeal carcinoma and HLA in Hubei

作　　者：姜汉英[1] 李婧[1] 胡国清[1] 刘东[1] 杜光[1] 方淑贤[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院,武汉430030

出　　处：《中国免疫学杂志》2005年第6期474-476,共3页Chinese Journal of Immunology

摘　　要：目的:探讨25例鼻咽癌患者和50例正常祖籍湖北汉族居民HLA-A,HLA-B位点抗原分型。方法:采用美国NIH标准微量淋巴细胞毒技术和免疫磁珠法分离TB淋巴细胞。结果:鼻咽癌患者组的HLA-A1,HLA-B63抗原频率明显高于正常对照组(P值分别为0.0098和0.0028)。结论:HLA-A1可能是湖北或华中地区鼻咽癌患者相关的一种区域性抗原,而HLA-B63可能是一个新的鼻咽癌相关的抗原。Objective:To study the HLA-A and HLA-B antigen type of 25 patients with NPC and 50 normal healthy individuals in Hubei province.Methods:T, B lymphocytes were isolated by American NIH standard lympho cytotoxic technique and magnetic beads method.Results:The result showed that the antigen frequencies of HLA-Al and HLA-B63 were significantly higher in NPC patient group than in normal control group(P=0.009 8 and P=0.002 8, respectively) and the antigen frequency HLA-11 was significantly lower in NPC patient group than in normal control group(P=0.007 5, RR=0.26) .Besides these,the A2-B17 Jointed occurrence was increased in NPC patient group(P = 0.035,RR=9.6).Conclusion:The result suggested that HLA-Al was associated with NPC in Hubei or central China.HLA-B63 might be a new kind of antigen which was associated with NPC.

关 键 词：鼻咽癌 HLA抗原 抗原频率 

分 类 号：R392.2[医药卫生—免疫学]