儿童临床病例柯萨奇B组病毒感染调查  

Epidemiologic distribution of CoxB virus in Child infection

作　　者：张丹[1] 张光萍[1] 刘秀珍[1] 

机构地区：[1]武汉市儿童医院检验部

出　　处：《华中医学杂志》2005年第3期219-220,共2页Central China Medical Journal

摘　　要：目的探讨本地区儿童感染柯萨奇B组病毒(CoxB)主要血清型流行病学分布。方法采用ELISA方法,检测住院感染性疾病儿童血清CoxBIgM4142例,并对9例髋关节滑膜炎患儿髋关节腔液进行病毒分离培养,利用中和试验鉴定病毒型别。结果CoxBIgM阳性370例,总阳性检出率为8.9%,对其中85例阳性标本进行了CoxB16型血清分型检测,其中CoxB3占54.1%,CoxB4占30.6%,首次在9例髋关节腔液病毒分离CoxB3病毒1株,并被其患儿恢复期血清所中和,其CoxBIgG有4倍增高。结论CoxB3和CoxB4是本地区的主要感染型。Objective To survey the main serotype of CoxB virus in child infection.Methods Enzyme Linked Immcnosorbent assay (ELISA) was used to detect IgM anti-CoxB virus in 4 142 cases of children with infections;9 cases of sterile joint fluid of children with coxitis were cultred for the Separation of CoxB virus, and neutralization test was used to identify its type.Results The positive rate of IgM anti-CoxB virus in children with infections disense was 8.9 %. CoxB 3was the major serotype of CoxB virus, which is 54.1 %, next was CoxB 4, which was 30.6 %. CoxB 3 virus was separated from the joint fluid and IgM level in stage of recovery was 4 time higher than acute phase.Conclusion CoxB 3 and CoxB 4 were the major serotype of CoxB virus in children of Wuhan area.

关 键 词：柯萨奇B组病毒 感染调查 临床病例 ELISA方法 CoxB3 流行病学分布 病毒分离培养 髋关节滑膜炎 CoxB病毒 关节腔液 感染性疾病 IGM阳性 阳性检出率 儿童感染 中和试验 分型检测 阳性标本 血清型 恢复期 感染型 患儿 

分 类 号：R725.1[医药卫生—儿科]