老年高血压患者颈动脉病变与C反应蛋白的相关研究  

Study on Relationship between Carotid Artery Atherosclerosis and Serum CRP in Elderly Hypertensive Patients

作　　者：袁惠敏[1] 沈丽[1] 杨卫红[1] 潘志红[1] 张江蓉[1] 王一尘[1] 

机构地区：[1]上海第二医科大学附属新华医院老年科,上海200092

出　　处：《中国医师杂志》2005年第6期774-776,共3页Journal of Chinese Physician

摘　　要：目的研究老年原发性高血压患者颈动脉粥样斑块与血清C反应蛋白(CRP)的关系。方法100例老年原发性高血压患者,其中男93例,女7例,平均年龄73±7岁。应用超声多普勒对所有病例的颈动脉进行检查,检测颈动脉内膜中层厚度(IMT)及粥样斑块。用免疫学方法测定血清中CRP浓度,然后分析超声结果与CRP浓度的关系。结果随着IMT增厚,CRP浓度亦增高(P<0.05)。高血压级别越高,IMT越厚,不同级别间相比较差异有显著性(P<0.05)。粥样斑块1、2、3级CRP浓度高于粥样斑块0级(P<0.05)。结论老年原发性高血压患者血清中CRP浓度与颈动脉IMT、斑块级别呈正相关,CRP对判断动脉粥样硬化程度具有一定的意义,可作为了解动脉粥样硬化程度、指导治疗、判断预后的指标。Objective To study the relationship between carotid artery atherosclerosis and serum C-reactive protein(CRP) in elderly patients with essential hypertension. Methods 100 hypertensive patients(mean age 73±7 years), including 93 males and 7 females were enrolled in this study. Colour Doppler ultrasonography was used to measure intima-media thickness(IMT) and atherosclerotic plaque of carotid arteries. Serum CRP was determined with immunological method. The relationship between the result of ultrasonography and CRP concentration was analyzed. Results CRP concentration was positively correlated with IMT(P<0.05). IMT had an increasing trend with the severity of hypertension, and was significantly different among various grades of hypertension(P<0.05). CRP concentration in the patients with atherosclerotic plaque was higher than that in the patients without one(P<0.05). Conclusion CRP concentration was positively correlated with IMT and degree of atherosclerotic plaque in elderly patients with essential hypertension. CRP was helpful for evaluating the severity of atherosclerosis, guiding treatment and predicting prognosis.

关 键 词：老年高血压患者 颈动脉病变 相关研究 原发性高血压患者 C反应蛋白(CRP) 颈动脉内膜中层厚度 动脉粥样硬化 颈动脉粥样斑块 颈动脉IMT 超声多普勒 免疫学方法 平均年龄 指导治疗 判断预后 浓度 血清 显著性 正相关 

分 类 号：R544.1[医药卫生—心血管疾病]