铝对兔神经系统的亚慢性毒作用研究  

Chronic Toxic Effects of Aluminum on Nervous Svstem in Rabbits

作　　者：张万起[1] 徐格晟[1] 黄国伟[1] 陈杰[1] 任大林[1] 陈蔼眉 

机构地区：[1]天津医科大学营养与食品卫生教研室

出　　处：《中华预防医学杂志》1994年第3期158-161,共4页Chinese Journal of Preventive Medicine

摘　　要：通过家兔３２周经口摄入硫酸铝钾实验，探讨了食品添加剂─—硫酸铝钾中铝在脑内蓄积及对中枢系统的毒作用。结果表明，随铝摄入量增加，血、脑铝含量明显增加（Ｐ＜０．０１）；血锌水平、超氧化物歧化酶及单胺氧化酶－Ｂ活性呈明显负相关。脑组织超氧化物歧化酶活性也与脑铝蓄积量呈显著负相关，过氧化脂质水平则与之呈显著正相关。病理学检查发现随铝摄入量及脑铝含量的增加，中央前回，海马和脊髓的病变愈严重和广泛。主要病理表现为神经微丝、微管排列紊乱及突触结构异常等。Twenty-one male rabbts were administered with alum(aluminum potassium sulfate)for 32 weeks to study the accumulative toxic effects of alumhum in food additives on central nervous system.Results showed aluminum levels in blood and brain tissue of the animals increased significantly with intake of alum(P <0.01).Blood zinc leveis,and activities of superoxide dismutase(SOD)and monoamine oxidase B(MAO-B)correlated negatively with aluminum levels in blood and brain,and SOD activity correlated negatively to accumulative aluminum deposit and positively to lipid oxide level in brain.Pathological examinations showed lesions in gyrus centralis anterior,gyrus hippocampi and spinal cord of the animals got more severely and extensively with aluminum intake and brain aluminum content,with disarrangement of neurofilaments and neurotubule,and deformation of synaptic structures.

关 键 词：铝 毒理学 神经系统 

分 类 号：R595.2[医药卫生—内科学]