18~F标记氟乙基胆碱的合成与动物显像  

Synthesis and animal imaging of^(18)F-FECh

作　　者：吴战宏[1] 王世真[1] 周前[1] 邱飞婵[1] 霍力[1] 滕宝[1] 程欣[1] 

机构地区：[1]中国医学科学院,中国协和医科大学北京协和医院核医学科,100730

出　　处：《中华核医学杂志》2005年第3期138-140,i001,共4页Chinese Journal of Nuclear Medicine

摘　　要：目的研制PET肿瘤显像剂18F氟乙基胆碱(FECh)。方法制备了FECh和18FFECh,进行了放化纯、稳定性分析及生物实验。结果产物结构通过1HNMR谱的确认,采用手动和半自动合成装置完成标记,合成过程简便,收率稳定,放化纯>99%,稳定性好。18FFECh的正常小鼠分布与文献报道的11Ccholine相似,毒性较小;18FFECh在荷瘤鼠的肿瘤部位有浓集。结论18FFECh可以成为较好的肿瘤阳性显像剂。Objective To synthesize 18F-fluoroethylcholine (FECh) and imaging in animal as an oncologic PET tracer. Methods Synthesis of 18F-FECh was modified from Hara's method. The radiochemical purity was measured by high performence liquid chromatography (HPLC). The biodistribution in normal mice and the stability were studied. PET imaging with 18F-FECh was performed on tumor xenograft murine models. Results 18F-FECh was synthesized with stable radiochemical yield and its radiochemical purity was over 99%. Remote-control-manipulator and semiautomatic apparatus were used to radiosynthesize 18F-FECh with low toxicity. The biodistribution showed high uptake in liver, kidney, heart and low uptake in brain, blood, similar to 11C-choline as reported in literature. 18F-FECh PET imaging showed uptake in S-180 sarcoma bearing KM mouse and glioma bearing nude mouse. Conclusion 18F-FECh can be used as an oncologic PET tracer.

关 键 词：^18F标记 胆碱 乙基 肿瘤阳性显像剂 动物 氟 肿瘤显像剂 生物实验 NMR谱 产物结构 自动合成 文献报道 正常小鼠 肿瘤部位 稳定性 PET 分析及 ^1H 荷瘤鼠 

分 类 号：TQ421.7[化学工程]