复方盐酸二甲双胍片中格列本脲和二甲双胍溶出度的考察  

Investigation on the dissolution rates of glibenclamide and metformin in compound metformin hydrochloride

作　　者：石英[1] 刘松青[1] 

机构地区：[1]第三军医大学西南医院药学部,重庆400038

出　　处：《第三军医大学学报》2005年第11期1117-1119,共3页Journal of Third Military Medical University

摘　　要：目的　考察并比较自制复方二甲双胍片中格列本脲、二甲双胍与对照药格列本脲片、二甲双胍片的溶出度。方法　以HPLC法测定含量,用转篮法测定溶出度,并就溶出度进行比较。结果　经检测制剂工艺不同的格列本脲、二甲双胍体外溶出度均符合《中国药典》2 0 0 5年版的规定,但溶出参数各不相同。结论　经统计学处理,因制剂工艺不同,复方二甲双胍片中格列本脲溶出度有显著性差异而二甲双胍溶出度差异不显著。Objective To investigate the dissolution rates of glibenclamide and metformin in compound metformin hydrochloride. Methods The concentrations of the glibenclamide and metformin were determined by HPLC method. The rotating basket method was used to measure and compare the dissolution rates of glibenclamide and metformin between the compound metformin hydrochloride and conventional tablets. Results The dissolution rates of glibenclamide and metformin with different preparation came up to the standard of CHP (2005), but the dissolution parameters were different. Conclusion The dissolution rate of glibenclamide indicated significant difference between the compound metformin hydrochloride and the conventional tablets, and no significant difference for metformin.

关 键 词：格列本脲 二甲双胍 溶出度 HPLC法 

分 类 号：R313[医药卫生—基础医学] R914.3