颈交感神经阻滞对放烧复合伤小鼠的治疗作用  

Roles of cervical sympathetic ganglia block in the treatment of mice with combined radiation and burn injury

作　　者：陆建华[1] 粟永萍[1] 程天民[1] 杜智勇[1] 

机构地区：[1]第三军医大学军事预防医学院防原医学教研室,全军复合伤研究所,创伤,烧伤与复合伤国家重点实验室,重庆400038

出　　处：《第三军医大学学报》2005年第12期1253-1255,共3页Journal of Third Military Medical University

基　　金：国家重点基础研究发展规划资助项目 ("973"项目 ;G19990 54 2 0 1)~~

摘　　要：目的　探讨颈交感神经阻滞对放烧复合伤小鼠的治疗作用,明确颈交感神经阻滞可否成为严重创伤后续损害简单有效的治疗手段。方法　TBSA 15 %Ⅲ度烧伤合并5Gy放射损伤小鼠分为SB治疗组(颈部注射利多卡因)及对照组(未给予SB治疗) ,观察两组动物2、5、7、10、15、2 0、3 0d死亡率及7、14、2 1d外周血RBC、WBC、BLT计数的变化,另外还观察SB治疗对放烧复合伤后3、6、14d血清TNF α、IL 1β、IL 6的影响。结果　SB治疗使放烧复合伤后5、7、10、15、2 0、3 0d的死亡率显著降低;使伤后7、14、2 1d血白细胞、红细胞及血小板数显著增加;使伤后3、6、14d的血清炎性细胞因子TNF α,IL 1β、IL 6水平显著下降。结论　SB显著降低放烧复合伤动物的死亡率,可以成为严重创伤简单有效的治疗手段;SB降低放烧复合伤动物死亡率可能是通过促进造血功能的恢复、抑制过度的炎性反应而实现的。Objective To determine the feasibility of cervical sympathetic ganglia block (SB) therapy for the treatment of mice with combined radiation and burn injury. Methods Kunming mice inflicted with 5 Gy irradiation and 15% TBSA full thickness burn injury were divided into control group (untreated by SB) and SB group (treated daily by SB ). The roles of SB were evaluated by comparing mortality, peripheral blood RBC, WBC, PLT counting and serum TNF-α, IL-1β, IL-6 levels in each group. Results As compared with the control group, the mortality in SB group decreased significantly at 5, 7, 10, 15, 20, 30 d after combined radiation and burn injury and peripheral blood RBC, WBC, PLT increased and serum TNF-α, IL-1β, IL-6 levels decreased obviously in SB group. Conclusion SB is an effective central therapeutic approach for the treatment of combined radiation and burn injury. SB can accelerate restoration of haematogenesis function and regulate systemic inflammatory responses, which may be the mechanisms for effectiveness of SB on mortality in mice with combined radiation and burn injury.

关 键 词：颈交感神经节 阻滞 放烧复合伤 死亡率 造血 细胞因子 

分 类 号：R338.7[医药卫生—人体生理学] R644[医药卫生—基础医学]