烧伤后瘢痕癌五例报告  

Carcinoma arising from postburn scars(report of 5 cases)

作　　者：柴家科[1] 盛志勇[1] 郭振荣[1] 陈文元[1] 朱兆明[1] 梁延杰[2] 蓝复生 

机构地区：[1]北京中国人民解放军第三○四医院烧伤整形科,100037 [2]北京中国人民解放军第三○四医病理科,100037

出　　处：《中华整形烧伤外科杂志》1994年第3期183-185,共3页

摘　　要：自1958年～1992年间共救治烧伤瘢痕癌共5例,均为男性,平均年龄56岁,其发病率仅为同期救治的烧伤瘢痕挛缩畸形病例总数(1563例)的0.32%。本组资料表明:下肢和关节活动部位为烧伤瘢痕癌的好发部位,且烧伤时年龄愈小,其发生恶变所需的时间愈长。本组5例,经病理诊断(采用特殊组化染色方法)均为鳞状细胞癌(以下简称鳞癌),其中4例为Ⅰ级,1例为Ⅱ级。我们认为病变部位的多处病理活检是诊断烧伤后瘢痕癌的主要手段。我们还就烧伤瘢痕癌的病理诊断、治疗及预防进行了讨论。Carcinoma arising from postburn scars is rare.We have encountered 5 pa- tients suffering from this late complication of scars,accounting for 0.32% of 1563 admis- sions for late surgery after burn injuries.They were all males,with a mean age of 56 years. The mean latent period was 43.2 years,and it was apparently longer when the acute burn injury occurred earlier in life.The site of predilection was the lower extremity,and multiple biopsies of various sites of the lesion remained to be the measure of confirmation.Pathologi- cally,they were all squamoon cell carcinoma,grade Ⅰ in 4 cases and grade Ⅱ in 1.Immunohis- tochemical staining with anti-proliferation cell nuclear antigen (PCNA) showed that PCNA positive nuclei of squamous cell carcinoma were more numerous,as compared with that in the neighboring pseudo-epitheliomatous hyperplasia (PEH) and in normal skin,denoting markedly augmented assimilation of DNA in malignant degeneration.On the contrary,the number of Langerhan's cells were smallest in cancer area,as compared with PEH and normal skin.The diagnosis,treatment and prevention of such malignant degeneration in postburn scars have been discussed.

关 键 词：瘢痕癌 烧伤 病例报告 

分 类 号：R644[医药卫生—外科学]