干贝素的抗癫痫作用  

Antiepileptic effect of sodium succinate

作　　者：章政[1] 李静[1] 聂惠贞[2] 王蕾[2] 岳旺[2] 

机构地区：[1]青岛大学医学院附属医院神经科 [2]青岛大学医学院药理教研室,山东青岛266021

出　　处：《中国海洋药物》2005年第3期33-35,共3页Chinese Journal of Marine Drugs

基　　金：国家教委部;青岛市科技局课题(No.9532;No.022kjyj31)

摘　　要：干贝素(Sodiumsuccinate)灌胃给药(0.8g·kg-1),在大鼠杏仁核点燃的慢性癫痫模型上,可缩短点燃后放电时程ADD(P<0.05),降低Racine’s分级(P<0.01);初步临床使用中观察到一些常规口服抗癫痫药物效果不理想的癫痫患者,加服干贝素胶囊显示出很好的疗效。Sodium succinate (0.8 g·kg~ -1,ig) could significantly shorten afterdischarge duration (ADD), lower Racine’s score on amygdala electrical kindling in rat.Additional sodium succinate capsule (0.25g,po) was effective on patients with epilepsy administrated with common antiepileptic drugs which showed little effectiveness on these patients. The results supposed sodium succinate would be effective in epilepsy therapy.

关 键 词：干贝素 癫痫 点燃 

分 类 号：R971.6[医药卫生—药品]