sTRAIL与HBV感染临床转归的研究  

Soluble tumor necrosis factor related apoptosis inducing ligand (sTRAIL) and clinical outcome of HBV infection in human

作　　者：岳凤娥[1] 刘典勇[2] 宋静[2] 张利宁[2] 

机构地区：[1]济南市传染病医院,250021 [2]山东大学医学院

出　　处：《中华实验和临床病毒学杂志》2005年第2期146-148,共3页Chinese Journal of Experimental and Clinical Virology

基　　金：济南市卫生局基金资助

摘　　要：目的　探索可溶性肿瘤细胞坏死因子相关凋亡诱导配体(sTRAIL)在HBV感染人体所致的各型乙型肝炎(乙肝)和原发性肝癌发病机制中的作用。方法　采用ELISA法检测15 3例各型肝病患者血清sTRAIL水平,同时检测肝功能相关指标,并进行相关性分析。结果　各型肝病发病期患者血清sTRAIL水平显著高于正常对照组;恢复期患者血清sTRAIL水平接近正常组;急、慢性乙肝患者血清sTRAIL水平与丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)和血清胆红素(TBIL)均呈显著负相关,与血清白蛋白(ALB)水平呈显著正相关。结论　sTRAIL水平增高与肝损伤相关,sTRAIL诱导细胞凋亡是肝细胞损伤的机制之一。Objective To explore the role of sTRAIL in the pathogenesis of HBV infection in human being. Methods sTRAIL in 153 patients' sera was examined with ELISA. Correlations between sTRAIL and liver functional parameters were analysed. Results The levels of sTRAIL in patients with various clinical types of hepatitis B as well as primary hepatocellular carcinoma were all higher than that in normal persons and became almost normal in recovering stage cases. In acute and chronic HBV infection, sTRAIL level was negatively correlated with ALT, AST and total bilirubin levels, and positively correlated with serum albumin. Conclusion The results indicated that higher level of sTRAIL expression is correlated with liver damage, and apoptosis induced by sTRAIL is one of the mechanisms of liver damage in HBV infection.

关 键 词：STRAIL HBV感染 临床转归 相关凋亡诱导配体 肿瘤细胞坏死因子 ELISA法检测 天冬氨酸转氨酶 丙氨酸转氨酶 慢性乙肝患者 诱导细胞凋亡 原发性肝癌 相关性分析 正常对照组 血清胆红素 血清白蛋白 肝细胞损伤 发病机制 乙型肝炎 

分 类 号：R512.62[医药卫生—内科学]