妊娠高血压综合征患者血清β绒毛膜促性腺激素及胎盘催乳素水平测定及其临床意义  

Human serum choriogonadotrophin β and placenta lactogen in pregnancy-induced hypertension syndrome and their clinical significance

作　　者：李春江[1] 孙蕾[2] 曹雪梅[2] 

机构地区：[1]佳木斯大学基础医学院,黑龙江佳木斯154007 [2]佳木斯市中心医院,黑龙江佳木斯154002

出　　处：《黑龙江医药科学》2005年第3期37-38,共2页Heilongjiang Medicine and Pharmacy

摘　　要：目的:探讨血清β绒毛膜促性腺激素(β-hCG)及胎盘催乳素(HPL)的临床意义及其在妊娠高血压综合征(妊高征)发病中的作用.方法:用放射免疫法测定142例正常妊娠妇女(正常妊娠组)及43例妊高征妇女(妊高征组,其中轻度16例,中度12例,重度15例)血清β-hCG及HPL水平。结果:(1)轻、中、重度妊高征妇女血清β-hCG分别为(25.33±17.80)μg/L、(33.12±4.91)μg/L、(42.19±17.47)μg/L;正常妊娠妇女为(12.33±7.92)μg/L,妊高征组与正常妊娠组比较,差异有极显著性(P<0.01)。β-hCG水平与妊高征病情严重程度呈正相关(r=0.677,P<0.05)。(2)轻、中、重度妊高征妇女血清HPL分别为(14.73±3.26)mg/L、(11.44±4.02)mg/L、(12.73±4.18)mg/L;正常妊娠妇女为(12.78±4.67)mg/L。妊高征组与正常妊娠组比较,差异无显著性(P>0.05)。HPL水平与妊高征病情严重程度无相关(r=-0.300,P>0.05)。结论:β-hCG可反映妊高征时滋养细胞功能紊乱的程度及病情严重程度,可作为妊高征病情的监测指标之一。HPL水平的变化不能作为妊高征的检测指标。Objective: To examine the levels of human serum choriogonadotrophin β (β-hCG) and placental lactogen (HPL) in the sera of normal pregnant women and patients with pregnancy-induced hypertension syndrome (PIHS) and to study their clinical significance and their effects on the onset of the disease. Methods: Serum levels of β-hCG and HPL of 142 normal pregnant women and 43 patients with PIH (16 mild, 12 moderate and 15 severe) were determined by radioimmunossay. Results: (1) Serum levels of β-hCG in all PIHS were (25.33±17.80)μg/L in mild, (33.12±4.91)μg/L in moderate and (42.19±17.47)μg/L in severe ,and were significantly higher than those of the normal pregnant group [(12.33±7.92)μg/L; P<0.01]. There was a positive correlation between the β-hCG level and PIHS degree (r=0.677,P<0.05). (2) Serum levels of HPL in all PIHS were (14.73±3.26)mg/L in mild,(11.44±4.02) mg/L in moderate and (12.73±4.18)mg/L in severe and did not show significant difference when compared with those of normal pregnant group [(12.78±4.67)mg/L;P>0.05]. Furthermore, there was no correlation between the HPL level and PIHS degree (r=-0.300,P>0.05).Conclusion: Serum β-hCG level can reflect the degree of functional disorder of the placental trophoblast on PIHS, which may be used as a clinical detection index of PIHS. On the other hand, the change of HPL level is not used as a factor.

关 键 词：妊娠并发症 心血管 高血压 促性腺激素类 绒毛膜 催乳素 孕妇 

分 类 号：R714.246[医药卫生—妇产科学]