噻吩-2,5-二羧酸的合成  

Synthesis of 2,5 -Thiophenedicardoxylic Acid

作　　者：丁为民[1] 吴宝华[1] 赵春山[1] 

机构地区：[1]哈尔滨理工大学化学与环境工程学院,黑龙江哈尔滨150040

出　　处：《哈尔滨理工大学学报》2005年第3期60-62,共3页Journal of Harbin University of Science and Technology

基　　金：黑龙江省教育厅科学技术研究项目(10531054)

摘　　要：为缩短合成噻吩-2,5-二羧酸的反应时间,得到适合于工业化生产的工艺条件,利用己二酸与氯化亚砜直接氯化、关环的反应,对噻吩-2,5-二羧酸合成工艺条件进行研究.结果表明,适合工业化的工艺条件为:己二酸用量为10g,氯化亚砜总用量为45mL,氯化亚砜分两次加入, 第一次加入氯化亚砜15mL,第二次加入氯化亚砜30mL;当反应温度达105℃时,加入乙酰氯3mL; 反应总时间为20h,反应时间较传统工艺缩短了10h,产品收率为72.1%.In order to decrease reaction time and adapt to industrialization, in the text chlorinating directly and cyclizing reaction of adipic acid with thoinly chloride is described, moreover, we study on synthesis technics of 2, 5 - thiophene dicarboxylic acid. 2,5- thiophene dicarboxylic acid is formed by 10g of adipic acid and thoinly chloride 45mL which is first added into 15mL then into 30mL; when temperature getting to 105℃ , added into acetyl chloride 3mL. Total reaction time is about 20h which reduce 10h than other literatures and the yield is 72. 1%.

关 键 词：噻吩-2 5-二羧酸 己二酸 氯化亚砜 合成 

分 类 号：O626.12[理学—有机化学]