延髓左侧腹外侧神经血管压迫致高血压的动物实验研究  

Experimental study of essential hypertension related to neurovascular compression at the left lateral medulla

作　　者：沈加林[1] 陈克敏[2] 罗其中 许建荣[1] 张晓华 李善泉 

机构地区：[1]上海第二医科大学附属仁济医院放射科,200001 [2]上海第二医科大学附属瑞金医院放射科 [3]仁济医院神经外科

出　　处：《中华神经外科杂志》2005年第6期379-382,共4页Chinese Journal of Neurosurgery

基　　金：上海市自然科学基金项目(99ZB14021)

摘　　要：目的探讨神经源性高血压的发生机制。方法放免法测定动物模型建立前后其血浆中肾素活性、血管紧张素Ⅱ浓度;实验动物模型建立前后神经病理学与投射电镜检查。结果⑴高血压组犬术后4个阶段所记录动脉收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)及心率(HR)分别较术前均有明显升高(P<0.001);对照组犬模型建立前后SBP、DBP、MAP及HR等观察指标差异无统计学意义(P>0.05)。⑵对照组犬模型建立前、后PRA及ANGⅡ浓度变化均无统计学意义(P>0.05);高血压组犬模型建立后PRA及ANGⅡ浓度均较模型建立前有明显变化,统计学上有统计学意义(P<0.05)。⑶神经病理学及透射电镜检查示高血压组犬神经脱髓鞘等有异常表现。结论左侧延髓腹外侧Ⅸ、Ⅹ颅神经REZ动脉血管压迫所导致的高血压的发生与左侧延髓血管运动中枢对血压的调节失衡有关。Objective To explore the possible mechanisms of neurogenic hypertension.Methods The plasma concentration of angiotensinⅡ (AngⅡ) and plasma renin activity (PRA) were analysed by radioimmunoassay (RIA).Experimental animals underwent pathologic and electron microscopic examinations before and after operation respectively. Results ⑴ Statistically,SBP,DAP,MAP,and HR of postoperation were more significantly increased than preoperation in hypertension group (P<0.001),but not in control group (P>0.05).⑵ There was significant difference between postoperative and preoperative concentration of PRA/AngⅡ in hypertension group(P<0.05),and no significant difference inocontrol group(P>0.05).⑶ Pathological findings showed demyelination, electron microscope demonstrated widened lamellae,and myelin degradation of the myelin sheath in hypertesion group. Conclusions Essential hypertension caused by neurovascular compression of the left ventrolateral medulla was associated with malbalance of vasomotor center in the dorsal medulla

关 键 词：动物实验研究 神经血管压迫 左侧 动物模型建立 神经源性高血压 神经病理学 血管紧张素Ⅱ 高血压组 心率(HR) 透射电镜检查 ANGⅡ 放免法测定 动脉收缩压 平均动脉压 神经脱髓鞘 延髓腹外侧 统计学 犬模型 发生机制 肾素活性 

分 类 号：R544.1[医药卫生—心血管疾病]