低强度脉冲超声治疗关节软骨缺损的超微结构研究  

The ultrastructure of articular cartilage defect after treatment by low intensity pulsed ultrasound

作　　者：贾小林[1] 陈文直[2] 王智彪[2] 

机构地区：[1]重庆市中山医院骨科,400013 [2]重庆医科大学医学超声工程研究所

出　　处：《中国康复医学杂志》2005年第6期412-413,F005,共3页Chinese Journal of Rehabilitation Medicine

基　　金：国家自然科学基金重点项目(39630340)

摘　　要：目的:观察低强度脉冲超声治疗兔关节软骨缺损的效果。方法:在21只兔股骨内侧髁软骨面处钻孔,作为动物模型。术后左后肢膝关节缺损处以低强度脉冲超声辐射作为治疗侧,右后肢予以假辐射作为对照侧。分别于术后2周、4周和8周全部处死取材,作透射电镜检查。结果:治疗侧软骨缺损修复速度及修复组织质量均比对照侧高。结论:低强度脉冲超声能有效地治疗关节软骨缺损。Objective:To observe the effects of articular cartilage defect after treatment by low intensity pulsed ultrasound(LIPU) through transmission electron microscope.Method:Twenty-one adult New Zealand white rabbits with bilateral, full-thickness osteochondral defects in the cartilage surfaces of medial condyles were used. The left knees in these animals were treated. The right knees were not treated.Groups of 7 animals each were sacrificed at 2,4 and 8 weeks postoperative for transmission electron microscope.Result:Ultrasound treatment could accelerate the repairing of cartilage defect and the quality of repaired tissues was better than nontreated controls.Conclusion:LIPU is effective to treat articular cartilage defect.

关 键 词：低强度脉冲超声 软骨 缺损 超微结构 

分 类 号：R684[医药卫生—骨科学]