丙型肝炎患者尿液特异标志物的检测及其临床意义  

SIGNIFICANCE OF DETECTING ANTI-HCV AND HCVRNA IN URINE IN PATIENTS WITH HCVV INFECTION

作　　者：肖杰生[1] 高志良[1] 陈文思[1] 陈青[1] 江元森[1] 俞洪林[1] 

机构地区：[1]中山医科大学附属第三医院传染病科

出　　处：《中山医科大学学报》1994年第3期200-202,共3页Academic Journal of Sun Yat-sen University of Medical Sciences

摘　　要：对５４例丙型肝炎患者尿液特异指标检测，结果：抗－ＨＣＶ阳性５／５４例（９．２％）。ＨＣＶＲＮＡ阳性９／５４例（１６．７％）。急性ＨＣＶ感染者，尿中抗－ＨＣＶ检出率为２／６例（３３％），较慢性者３／３８例（７．９％）为高（Ｐ＜０．０５）。尿液ＨＣＶＲＮＡ全部出现在未经α－干扰素治疗的慢性患者中，故可用作判断干扰素疗效的指标之一。本文在尿中检出ＨＣＶＲＮＡ，提示ＨＣＶ可经尿液污染环境。nti-HCV and HCV RNA were detected in urine of HCV infectious patients with EIA and polymerase chain reaction techniques. In 54 cases , it was found that 5 (9.2% ) were posi- tive for anti-HCV and 9 ( 16. 7% ) were positive for HCV RNA. Anti - HCV positivity was higher in patients with acute HCV infection ( 33 % ) than in patients with chroine HCV infec tion (7.9%). HCV RNA was positive only in chronic hepatitis C patients who had not beentreated with α-interferon. It indicated that detecting the markers of HCV in urine is helpful tojudge the curative effect during the treatment of α-interferon.

关 键 词：丙型肝炎病毒 尿液 聚合酶链反应 

分 类 号：R512.630.5[医药卫生—内科学]