自体抗体与反复流产的关系  

Relationship between recurrent spontaneous abortion and auto-antibodies

作　　者：张新宇[1] 武卉[1] 孙久惠[2] 孙淑岩 杨晶[1] 

机构地区：[1]大连医科大学第一临床学院,辽宁大连116011 [2]普兰店市第一人民医院,辽宁普兰店116200 [3]大连市妇幼保健院,辽宁大连116023

出　　处：《大连医科大学学报》2005年第3期185-188,共4页Journal of Dalian Medical University

摘　　要：[目的]探讨反复流产(RSA)与自身抗体,包括抗心磷脂抗体(aCL)、抗子宫内膜抗体(EmAb)和抗精子抗体(AsAb)的关系。[方法]对116例原因不明RSA患者(研究组)和40例正常非孕妇女(对照组),采用酶联免疫吸附法检测血清aCL和EmAb;采用凝集试验法检测AsAb。其中,研究组又按不同人流次数分为4组。[结果]整个研究组中aCL、EmAb和AsAb的阳性百分比均高于对照组,差异均有显著性(P<0.05),且人工流产次数与血清EmAb阳性率呈正直线关系(r=0.996)。[结论]体内aCL、EmAb和AsAb的存在可能是原因不明RSA的病因之一,且EmAb可能与人工流产导致后来反复自然流产有关。[Objective] To investigare the relationship between recurrent spontaneous abortion and autoantibod- ies,including anticardiolipid antibody(aCL)a、ntiendometrial antibody (EmAb)and antisperm antibody (AsAb). [Methods] Levels of serum aCL、EmAb were measured by enzyme linked immunosorbent assay (ELISA) and serum AsAb were performed by agglutination in 116 patients with RSA(study group)and 40 normal non preg- nant women (control group).The study group was further divided into 4 subgroup by different times of induced abortion.[Results] The positive rates of aCL,EmAb,AsAb in the study group were significantly higher than those in controls(P<0.05),moreover,the times of induced abortion and the positive rates of EmAb is positive linear correlation(r=0.996).[conclusions] This findings suggested that most patients with recurrent sponta- neous abortion of unknown etiology have a higher level of autoreactivity,which may affect the course of pregnan- cy.Furthermore,serum EmAb may be correlate with recurrent spontaneous abortion followed induced abortion.

关 键 词：抗心磷脂抗体 抗子宫内膜抗体 抗精子抗体 流产 反复 

分 类 号：R714.21[医药卫生—妇产科学]