尿脱氧吡啶啉及骨源性碱性磷酸酶在骨质疏松症中的临床意义  

Clinic significance of urinary deoxypyridinoline and bone alkaline phosphatase in osteoporosis

作　　者：霍维玲[1] 陈新军[2] 李香业[1] 王建强[1] 王继华[1] 

机构地区：[1]徐州医学院第二附属医院骨科,221006 [2]徐州医学院第二附属医院检验科

出　　处：《中国骨质疏松杂志》2005年第2期181-183,共3页Chinese Journal of Osteoporosis

摘　　要：目的探讨骨源性碱性磷酸酶(BAP)及尿脱氧吡啶啉(DPD)排泄率对骨质疏松症患者的诊断价值及两者的相关性。方法对73例骨质疏松症患者在其治疗前后进行血钙(Ca)、血磷(P)、血碱性磷酸酶(ALP)、血BAP、尿DPD、尿Cr及跟骨密度(BMD)测定,并同时测定50例正常健康人作对照。结果骨质疏松症患者BAP比正常对照组(213±8．13U／L 比142±6．69U／L)、DPD排泄率较正常对照组(6．11±2．14nmol／mmolCr比3．24± 1．62nmol／mmolCr)均明显增高(P<0．01),且治疗前后差异有显著性(P<0．01)。两者之间成正相关(r=0．52)。结论 BAP、DPD／Cr是监测骨质疏松症患者的敏感指标。Objective To investigate diagnostic value and association of BAP and excretion rate of DPD in osteoporosis. Methods Seventy-three patients with osteoporosis were tested for Ca2+ , P, ALP, BAP in serum, DPD, Cr of urine and BMD of Nol to 4 lumbar vertebra and the results was compared with that of 50 healthy people. Results Both of the BAP and excretion rate of DPD were higher than the control groups (P<0. 01) , and there was a great difference after therapy (P<0. 01) . A positive correlation was found between BAP and DPD/Cr. Conclusions BAP and DPD/Cr are sensitive index in monitoring osteoporosis.

关 键 词：骨源性碱性磷酸酶 骨质疏松症 临床意义 尿脱氧吡啶啉(DPD) 正常对照组 血碱性磷酸酶 治疗前后 正常健康人 诊断价值 同时测定 敏感指标 排泄率 BAP 患者 相关性 骨密度 显著性 正相关 Cr 

分 类 号：R723.244[医药卫生—儿科] R681[医药卫生—临床医学]