中药对绝经妇女下肢肌肉力量的影响  

Effect of the traditional Chinese herbs on muscular strength of lower limbs in postmenopausal women

作　　者：阮祥燕[1] 刘玉兰[1] 彭舟丽[1] 季颖[1] 陈宝英[1] 

机构地区：[1]首都医科大学附属北京妇产医院内分泌诊疗中心,北京100026

出　　处：《中国骨质疏松杂志》2005年第2期243-245,258,共4页Chinese Journal of Osteoporosis

基　　金：北京市中药局课题基金资助项目(2001);2000年度北京市科技新星计划项目基金资助[科星(2000)95号]

摘　　要：目的观察中药强骨胶囊(QGJN)对绝经妇女下肢肌肉力量的影响。方法选择自愿参加研究的绝经1a以上,年龄60岁以下,具有乏力等绝经相关症状,下肢肌肉力量不足的绝经妇女 150例,随机分为3组:中药+激素组(50例):采用中药QGJN联合雌激素戊酸雌二醇治疗;中药组(50例):单用中药QGJN治疗;激素组(50例):单用雌激素戊酸雌二醇周期序贯治疗;另 50例符合上述条件,暂不愿接受研究用药的绝经妇女作为对照组。各组均于治疗前及治疗后12w 采用肌肉功能分析仪测定下肢肌肉力量。结果中药+激素组(50例)、中药组(50例)、激素组 (50例)下肢肌肉力量较治疗前均有明显升高,增幅分别为25．23％±8．12％(P<0．01):11．71％±4．52％(P<0．01);12％±4．88％(P<0．01),其中,中药+激素组下肢肌肉力量升高幅值明显高于中药组(P<0．01)和激素组(P<0．01);而激素组上述指标较中药组略高,但差异无显著性(P>0．05);对照组(50例)的下肢肌肉力量明显下降,下降幅值为5．62％±2．38％(< 0．01)。结论中药强骨胶囊能提高绝经妇女下肢肌肉力量,其效果与雌激素戊酸雌二醇相仿,两药联用效果更好。Objective To observe the effect of the traditional Chinese herbs capsules QIANGGUJIAONANG (QGJN) on muscular strength of lower limbs in postmenopausal women. Methods Women who were under the age of 60 and one year after menopause with symptoms were chosen. One hundred and fifty women were randomly divided into 3 groups: combination of QGJN with estrogen treatment group (n=50); QGJN treatment group (n=50); estrogen treatment group (n=50). Another 50 cases were chosen as control without any above treatment. Muscular strength of lower limbs were measured before and 12 weeks after the treatment with Muscle Evaluation System (MES). Results The percentage of increasing muscular strength were 25. 23%±8.12% , 11. 71%±4. 52% and 12%±4. 88% , compared with the pre-treatment value, respectively. The increased value in the combination group were significantly higher than that of the estrogen and QGJN group (P<0. 01, respectively). The muscular strength reduced significantly in the control group by 5. 62%±2. 38% (P<0. 01). Conclusions The traditional Chinese medicine QIANGGU JIAONANG (QGJN) can increase muscular strength of lower limbs in postmenopausal women with insufficient muscular strength of lower hmbs. Whose effect is similar to Estradiol Valerate. Better effect might be achieved when QGJN plus Estradiol Valerate at the same time is better.

关 键 词：肌肉力量 绝经妇女 下肢 中药对 戊酸雌二醇 强骨胶囊 中药组 雌激素 方法选择 相关症状 序贯治疗 肌肉功能 联用效果 对照组 治疗前 60岁 分析仪 治疗后 显著性 单用 升高 下降 

分 类 号：R87[医药卫生—运动医学] R169.41[医药卫生—临床医学]