淫羊藿总黄酮对去除卵巢大鼠股骨头作用的扫描电镜观察与图像分析  

Study of effects of Epimedium Pubescen Flavonoid on femur of rat after ovariectomy

作　　者：濮祖茂[1] 李勇[1] 李晶晶[1] 季晖[1] 

机构地区：[1]中国药科大学,南京210009

出　　处：《中国骨质疏松杂志》2005年第2期246-250,共5页Chinese Journal of Osteoporosis

摘　　要：目的探讨淫羊藿总黄酮对去除卵巢大鼠骨质疏松防治作用。方法对股骨头组织形态进行了扫描电镜观察和图像分析。结果应用淫羊藿总黄酮治疗的大鼠骨小梁拱桥形结构有明显改善, 骨小梁拱桥形结构恢复其圆形或卵圆形,骨小梁间的距离变小、骨小梁直径增粗、骨表面较平整光滑。与用尼尔雌醇(E3)的治疗效果相似。结论从骨组织形态上证明淫羊藿总黄酮确具抗骨质疏松症的作用。Objective To explore the effect of Epimedium Pubescen Flavonoid (EPF) on preventing and treating the osteoporosis of rat after ovariectomy. Methods The histomorphometry and image analysis were performed. Results After treatment with EPF, the arch - like structure in bone trabecula was improved, significantly and changed into round or oval. The distence between bone trabeculae changed into less and the diameter of them became thicker. The surface of bone became smooth. The effect of EPF was similar to that of nylestriol in control. Conclusion EPF has the effect resisting osteoporosis.

关 键 词：淫羊藿总黄酮 扫描电镜观察 图像分析 股骨头 大鼠 卵巢 去除 抗骨质疏松症 骨组织形态 骨小梁 防治作用 治疗效果 尼尔雌醇 卵圆形 结构 

分 类 号：R285.5[医药卫生—中药学] R322.81[医药卫生—中医学]