单刀根化学成分的研究  

Studies on the Chemical Constituents from Roots of Lysidice rhodostegia Hance

作　　者：郜嵩[1] 浮光苗[1] 范丽华[1] 庾石山[1] 于德泉[1] 

机构地区：[1]中国医学科学院药物研究所,北京100050

出　　处：《中国天然药物》2005年第3期144-147,i001,共5页

基　　金：国家863计划(20022AA2Z343B);国家自然科学基金重点项目(20432030)~~

摘　　要：目的:研究豆科仪花属植物单刀根Lysidicerhodostegia的化学成分。方法:利用硅胶、SephadexLH20、HPLC等色谱方法进行化学成分的分离纯化,根据理化常数和光谱数据进行结构鉴定。结果:得到13个化合物,分别为(-)-5′-methoxyisolariciresinol3α-O-β-D-glucopyranoside(Ⅰ)、(+)5′methoxyisolariciresinol3α-O-β-D-glucopyranoside(Ⅱ)、()lyoniresinol3-α-O-β-Dglucopyranoside(Ⅲ)、白藜芦醇(resveratrol,Ⅳ)、羽扇豆醇(lupeol,Ⅴ)、2羟基羽扇豆醇(2hydroxylupeol,Ⅵ)、白桦酸(betulinicacid,Ⅶ)、sitosteryl3-β-glucoside6′Opalmitate(Ⅷ)、二十一酸-3-谷甾醇酯(heneicosanic3Oβsitosterolate,Ⅸ)、没食子酸(gallicacid,Ⅹ)、棕榈酸(palmiticacid,Ⅺ)、胡萝卜苷(daucosterol,Ⅻ)、β谷甾醇(βsitosterol,ⅩⅢ)。结论:13个化合物均为首次从单刀根中分离得到。AIM: To investigate the chemical constituents from the roots of Lysidice rhodostegia Hance.METHOD: The compounds were isolated by column chromatography on silica gel, Sephadex LH-20 and HPLC, their structures were identified by physicochemical properties and spectral data. RESULT: Thirteen compounds were isolated from the titled plant and were identified as(-)-5′-methoxyisolariciresinol 3α-O-β-D-glucopyranoside(Ⅰ),(+)-5′-methoxy-isolariciresinol 3α-O-β-D-glucopyranoside(Ⅱ), (-)-lyoniresinol 3α-O-β-D-glucopyranoside(Ⅲ), resveratrol(Ⅳ), lupeol(Ⅴ), 2-hydroxy-lupeol(Ⅵ), betulinic acid (Ⅶ), sitosteryl 3β-glucoside 6′-O-palmitate(Ⅷ), heneicosanic-3-O-β-sitosterolate (Ⅸ), gallic acid (Ⅹ), palmitic acid (Ⅺ), daucosterol (Ⅻ), β-sitosterol (ⅩⅢ). CONCLUSION: These compounds were obtained from Lysidice rhodostegia for the first time.

关 键 词：化学成分 SEPHADEX 羽扇豆醇 Β-谷甾醇 glu 分离纯化 色谱方法 HPLC 结构鉴定 光谱数据 理化常数 白藜芦醇 没食子酸 acid 胡萝卜苷 化合物 白桦酸 棕榈酸 

分 类 号：R284.1[医药卫生—中药学] R392-33[医药卫生—中医学]