补骨脂素脂质体凝胶的研制及体外释药研究  

Preparation of Psoralen Liposome Gel and its Drug-release Model in Vitro

作　　者：罗云[1] 何文[1] 李容凌[1] 

机构地区：[1]武汉大学人民医院药学部,武汉市430060

出　　处：《中国药房》2005年第10期746-747,共2页China Pharmacy

摘　　要：目的:制备补骨脂素脂质体凝胶并对其体外释药模式进行定量考察。方法:以同浓度的补骨脂素凝胶为对照组,用透析法检测补骨脂素脂质体凝胶(试验组)的体外释药模式,并对其在4℃下贮存3wk的释药稳定性进行研究。结果:与对照组比较,试验组具有明显的缓释及长效作用,且前3h释药符合Higuchi扩散模式(k=4. 67 %h-1/2) ,3h后遵循零级释药模式(k=0 .74 %h-1) ;对照组在试验的24h内释药符合Higuchi扩散模式(k=7. 18 %h -1/2) ;试验组在贮存期内的释药模式及包封率均维持稳定。结论:该制剂体外释药具有明显的缓释特征,稳定性较好。OBJECTIVE:To prepare psoralen liposome gel and to conduct a quan titative investigation about its drug reˉlease model in vitro.METHODS:Taken psoralen liposome gel that of the same concentration as the control group,the model of drug release in vitro of the testing group was evaluated by dialyzing method and the stability of its drug release after storage for3weeks at4℃was studied as well.RESULTS:Compared with the control group,the testing group showed significant slow-releasing and long-acting effects and the drug release followed the Higuchi(k=4.67%h -1/2 )diffusion model in the first3hours and a zero order drug release model(k=0.74%h -1 )3hours later;The drug release of the control group followed the Higuchi(k=7.18%h -1/2 )diffusion model of within24hours;The drug release model and the envelop rates of the testing group remained stable within the storage date.CONCLUSION:This preparation is characterized by slow drug releasing in vitro and good stability.

关 键 词：补骨脂素 脂质体凝胶 体外释药动力学 

分 类 号：R927.2[医药卫生—药学] R986