严重创伤患者血浆内毒素含量监测与抗菌药物应用的相关性研究  

Relationship between Plasma Endotoxin Levels and Administration of Antibiotics in Patients with Severe Traumatic Injury

作　　者：雒琪[1] 王复馨[1] 李军[1] 

机构地区：[1]山东省立医院,济南市250021

出　　处：《中国药房》2005年第10期758-760,共3页China Pharmacy

摘　　要：目的:探讨严重创伤患者术前、术后血浆内毒素含量的变化与抗菌药物应用的相关性。方法:应用动态浊度法对20例严重创伤患者分别在术前、术后应用不同抗菌药物的血浆内毒素含量变化进行动态检测,并设立正常对照组。结果:与正常对照组比较,严重创伤患者术前和术后早期血浆内毒素含量显著升高(P<0 .05) ,术后3d可达峰值,术后14d接近正常,且应用不同抗菌药物的各组间比较无显著性差异(P>0 .05)。结论:机体应激状态所致肠源性内毒素血症,可进一步加重机体的病理反应,故动态检测血浆内毒素含量的变化对临床治疗具有一定指导意义。OBJECTIVE:To discuss the relationship between the changes in pla sma endotoxin levels and use of antibiotics in patients with serious traumatic injury before and after operation.METHODS:The plasma bacterial endotoxin levels were dynamically detected by kinetic turbidimetric assay in20patients with severe traumatic injury used with different antibiotics before and after operation,at the same time the normal control group was established.RESULTS:Plasma endotoxin levels in patients with severe traumatic injury increased remarkably before and after operation,as compared with the normal control group(P<0.05),the levels reached peak value3days after operation and became normal14days after operation,while adˉministration of various antibiotics made no distinctly different effects on plasma endotoxin levels(P>0.05).CONCLUSION:Intestine-borne endotoxin induced in a stress condition can strengthen the pathological reaction of the body ,therefore dyˉnamic detection of plasma endotoxin can provide guidance for clinical therapy.

关 键 词：血浆内毒素 创伤 动态浊度法 

分 类 号：R927.12[医药卫生—药学]