高血压合并心房颤动对内皮细胞功能的影响  

Effects of Atrial Fibrillation Complicated with Hypertension on Endothelial Function

作　　者：李梅[1] 华琦[1] 刘荣坤[1] 杨铮[1] 

机构地区：[1]首都医科大学宣武医院心血管内科

出　　处：《首都医科大学学报》2005年第3期312-315,共4页Journal of Capital Medical University

摘　　要：目的探讨高血压合并心房颤动(简称房颤)对内皮细胞功能的影响。方法入选轻中度原发性高血压(简称高血压)患者88例,其中伴房颤者34例,分为高血压组和高血压合并房颤组2组,实验室测定血浆内皮素(ET)、一氧化氮(NO)水平,心脏超声下评价心脏结构和功能的各项指标。以34名健康人作对照组。结果高血压合并房颤组较高血压组左房内径显著增大,血浆ET水平和ET/NO比值均显著高于单纯高血压组和对照组(P<0.001),而血浆NO水平明显低于高血压组和对照组(P<0.001)。结论高血压合并房颤病人左房在原有高血压基础上进一步扩大,内皮细胞功能进一步下降。Objective To investigate the effects of atrial fibrillation complicated with hypertension on endothelial function. Methods Eighty-eight mild to moderate essential hypertension patients were enrolled. Thirty-four of them were complicated with atrial fibrillation. And patients were divided into two groups: hypertension and atrial fibrillation with hypertension. Plasma endothelin(ET), nitric oxide(NO) and indices of heart structure and function were measured by two-dimensional echocardiography. Thirty-four healthy persons matched in age and gender served as control. Results Left atrial diameter was significantly larger in atrial fibrillation with hypertension than in hypertension. Plasma ET level and ET/NO ratio were higher in atrial fibrillation with hypertension than other groups. And the atrial fibrillation with hypertension group had lower NO level as compared with other groups. Conclusion These findings suggest that atrial fibrillation has effects on atrial remodeling, which is based on hypertension effects. Endothelial function is seriously damaged and decreased in atrial fibrillation with hypertension patients.

关 键 词：内皮细胞功能 心房颤动 轻中度原发性高血压 血浆内皮素(ET) 心脏结构和功能 高血压组 血浆ET水平 实验室测定 对照组 一氧化氮 心脏超声 左房内径 NO比值 NO水平 健康人 

分 类 号：R544.1[医药卫生—心血管疾病] R541.75[医药卫生—内科学]