顺序注射停留分光光度法测定磺胺乙酰钠  

Sequential injection spectrophotometric determination of sulfacetamide sodium using the stopped-flow technique

作　　者：过治军[1] 冯素玲[1] 樊静[1] 

机构地区：[1]河南师范大学化学与环境科学学院河南省环境污染控制实验室,新乡453007

出　　处：《分析试验室》2005年第6期72-74,共3页Chinese Journal of Analysis Laboratory

摘　　要：在HCl浓度为5.0×10-4mol/L时,磺胺乙酰钠-NaNO2-1-萘胺的重氮化偶合反应,生成不稳定的红色产物,利用顺序注射停留技术在473nm波长处检测该不稳定产物,建立了快速自动测定磺胺乙酰钠的新方法。该方法线性范围为5～2500μg/mL,检出限为0.018μg/mL,进样频率为62个/h。应用于药物中磺胺乙酰钠的测定,并与药典规定方法进行对照。A rapid and simple sequential-injection spectrophotometric method using stopped-flow technique for the determination of sulfacetamide sodium was described. This method was based on the diazotisation of sulfacetamide sodium with sodium nitrite and coupling with 1-naphthylamine in 5.0×10^(-4) mol/L of hydrochloric acid. The measurements of unstablered product of the reaction were performed at 473 nm. The linear range was 5～2500 μg/mL, and the detection limit was 0.018 μg/mL. The method was applied to the determination of sulfacetamide sodium in drugs with the sample throughput of 62 h. The results were statistically compared with those obtained by pharmacopoeia method.

关 键 词：顺序注射分析 停留技术 分光光度法 磺胺乙酰钠 1-萘胺 

分 类 号：O657.32[理学—分析化学]