降糖胶囊对大鼠实验性高血糖的影响  

Effects of Jiangtang Capsules on experimental hyperglycemia in rats

作　　者：刘兵[1] 杨春梅[1] 徐华丽[2] 于小风[2] 曲绍春[2] 睢大员[2] 

机构地区：[1]武警吉林总队医院药剂科,长春130052 [2]吉林大学药学院药理教研室,长春130021

出　　处：《武警医学》2005年第6期414-417,共4页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的研究降糖胶囊对大鼠实验性高血糖的影响。方法制作大鼠实验性高血糖模型,测定降糖胶囊治疗性给药后动物的空腹血糖值及胆固醇、三酰甘油含量,并观察降糖胶囊对正常大鼠血糖及血清胰岛素含量影响。结果在舌下静脉注射2%四氧嘧啶造成大鼠实验性高血糖模型,降糖胶囊治疗性给药2周有明显降低血糖的作用,并能降低血清三酰甘油含量;在皮下注射0.1%肾上腺素造成大鼠实验性高血糖模型,降糖胶囊治疗性给药1周可明显降低血糖值;在腹腔注射葡萄糖造成大鼠实验性高血糖模型,降糖胶囊给药1周能明显降低血糖值;降糖胶囊对正常大鼠血糖及血清胰岛素含量均无明显影响。结论降糖胶囊对多种实验性高血糖模型均具有降糖作用,对正常大鼠血糖及血清胰岛素含量则无明显影响。Objective To study the effects of Jiangtang capsules (JTC) on experimental hyperglycemia in rats.Methods Fasting blood glucose, cholesterol and triglyceride were determined in rats with hyperglycemia induced with alloxan (2%, s.b), adrenalin (0.1%, s.c) or glucose (i.p), after administration of JTC. Blood glucose and insulin were also observed in normal rats treated with JTC.Results Blood glucose decreased significantly in models treated with JTC for 1 week, while blood glucose and insulin changed little in normal rats treated with JTC. Conclusion JTC possesses hypoglycemic action on hyperglycemia rat models, but has little effect on blood glucose and insulin in normal rats.

关 键 词：实验性高血糖 降糖胶囊 高血糖模型 胰岛素含量 正常大鼠 血清三酰甘油 空腹血糖值 血清胰岛素 注射葡萄糖 治疗性 含量影响 四氧嘧啶 静脉注射 降低血糖 肾上腺素 皮下注射 降糖作用 给药 胆固醇 显影 

分 类 号：R259.871[医药卫生—中西医结合] R977.2[医药卫生—中医内科学]