两种中药复方的药效动力学与测试成分药代动力学拟合——兼论中药药代动力学研究方法  

Assessment of Pharmacodynamics of Compound Preparations Made of Two Chinese Medicinal Herbes and Pharmacokinetics of Their Tested Components -and a Discussion on Study Method of Pharmacokinetics of Traditional Chinese Medicine

作　　者：杜力军[1] 邢东明[1] 赵玉男[1] 王雪莉[1] 苏慧[1] 卢弘[2] 孙虹[2] 金文[2] 

机构地区：[1]清华大学生物科学与技术系药物药理研究室,北京100084 [2]中国医学科学院中国协和医科大学药用植物研究所,北京100094

出　　处：《世界科学技术-中医药现代化》2005年第3期29-33,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：北京市科技计划项目(Z2004105040311):先导物和中药的ADMET性质快速集成评价实验平台清华大学基础研究基金(JC2000061):中药复方药物代谢动力学的方法学研究

摘　　要：在中药药代动力学研究中适时地引入药效动力学指标进行观察,将有助于提高对以有限的可测成分来反映受试中药体内动力学过程的表征性。但是如何进行药效动力学实验、如何选取测试指标、中药的药效动力学有何特点等,都是我们在进行中药药代动力学研究时所要考虑的问题。本文在已有研究的基础上,对比国外文献,对此问题进行了讨论。结果表明,在进行药效动力学实验时,应选择末端指标为主,从而能够从整体上反映和把握体内药效动态过程。In the research of pharmacokinetics of traditional Chinese medicine it is helpful, if pharmacodynamic indexes are timely introduced into observation, to improving the characterization of the dynamic process in vivo of the tested drugs even though the characterization represents limited components that can be tested from the drugs. Nevertheless, such problems as how to conduct the experiment of pharmacodynamics, how to choose testing indexes and what is the characteristics of pharmacodynamics of traditional Chinese medicine should be taken into consideration in the research. Based on the researches already done and in comparison with literatures abroad this article discusses these problems as mentioned above and holds that in the experiment of pharmacodynamics end indexes should be taken as the main choice so as to be able to reflect and grasp the dynamic process of curative effects in vivo as a whole.

关 键 词：药代动力学 药效 研究方法 中药复方 成分 动力学研究 动力学实验 拟合 动力学过程 力学指标 测试指标 动态过程 体内 

分 类 号：S859.796[农业科学—临床兽医学] S482.4[农业科学—兽医学]