乙酰丙酮钒在大鼠胃肠道吸收的初步研究  

A preliminary study of the absorption of vanadyl acetylacetonate at the rat's gastrointestinal tract

作　　者：张双庆[1] 潘铁成[1] 孙锋[1] 吕万良[1] 张垣[1] 张强[1] 

机构地区：[1]北京大学药学院药剂学系,北京100083

出　　处：《中国新药杂志》2005年第6期697-700,共4页Chinese Journal of New Drugs

摘　　要：目的:研究乙酰丙酮钒在大鼠胃、小肠和大肠的吸收特性。方法:采用大鼠在体灌流实验,用石墨炉原子吸收法测定大鼠血浆中钒(V)浓度。结果:乙酰丙酮钒在10mg·kg^(-1)剂量下在胃和大肠的吸收速率常数分别为2.853h^(-1)和0.587h^(-1),AUC分别为158.6ng·mL^(-1)·h和642.7ng·mL^(-1)·h;在不同给药剂量(以钒计)10,25和50mg·kg^(-1)时小肠的吸收速率常数分别为1.414,1.664和17.118h^(-1) ,AUC分别为1714.0,4641.2和5554.7ng·mL^(-1)·h。结论:大鼠胃和大肠是乙酰丙酮钒的不良吸收部位,而小肠有较好吸收,吸收方式可能是被动扩散。Objective: To characterize the absorption of vanadyl acetylacetonate (VAC) at the rat's gastrointestinal tract. Methods: VAC was delivered into the stomach, small intestine and large intestine of rats via cannulation in situ. Plasma vanadium concentrations were measured using graphite furnace atomic absorption spectrophotometry (GFAAS). Results: At 10 mg·kg^(-1), the absorption rate (ka) and AUC parameters of VAC were 2. 853h^(-1) and 158.6 ng·mL^(-1)·h in the stomach versus 0.587h^(-1) and 642.7ng·mL^(-1)·h in the large intestine, respectively. At 10,25 and 50 rag·kg^(-1), VAC was absorbed in the small intestine at a rate (ka) of 1.414,1.664 and 17.118h^(-1), respectively, and the AUC values were 1 714.0,4 641.2 and 5 554.7 ng·mL^(-1)·h, respectively. Conclusion: VAC was better absorbed in the small intestine with passive diffusion mechanism.

关 键 词：乙酰丙酮钒 在体胃肠吸收 石墨炉原子吸收法 

分 类 号：R965.1[医药卫生—药理学] R977.15[医药卫生—药学]