Analysis of Tablets Containing Estradiol Valerate and Norethisterone by HPLC  

作　　者：姜丽霞[1] 徐世芳[1] 金三九 娄金芳 

机构地区：[1]浙江省医学科学院药物研究所，杭州，310013 [2]杭州民生药业集团有限公司 [3]杭州赛利药物研究所

出　　处：《浙江省医学科学院学报》2005年第2期100-102,共3页

摘　　要：To develop a HPLC method for determination of estradiol valerate and norethisterone in compound batlets.Methods The chromatographic system consisted of Zorbax CN column and mobile phase of MeCN-H2O (47:53),with a detection wavelength at 280 nm.Progesterone was as the internal standard.Results The average (n=9)recovery both for estradiol valerate and norethisterone was 100.6% with RSD 0.9% and 100.2% with RSD 0.8%,respectively.Three batches of samples were analyzed,and satisfactory results were achieved.Conclusion Without complicated sampling procedure,the method was simple,rapid and accurate for the assay of the components in this pharmaceutical formulation.

关 键 词：雌二醇片剂 戊酸盐 高效液相层析技术 药物检查 

分 类 号：R927[医药卫生—药学] R944.4