磷脂酶A_2抑制剂及抗氧化剂对内毒素所致生物膜损伤的保护作用研究  

STUDIES ON THE PROTECTIVES EFFECTS OF PHOSPHOLIPASE A2INHIBITORS AND ANTIOXIDANT ON BIOMEMBRANES INJURIES IN-DUCED BY ENDOTOXIN ADMINISTRATION IN WISTAR RATS

作　　者：吕礼应[1] 康格非[1] 

机构地区：[1]安徽医科大学附一院检验科

出　　处：《重庆医科大学学报》1994年第2期94-96,共3页Journal of Chongqing Medical University

基　　金：四川省卫生厅资助

摘　　要：本文研究了磷脂酶Ａ＿２抑制剂（氯丙嗪、地塞米松）及抗氧化剂（维生素）对内毒素所致红细胞膜损伤的保护作用。结果表明：上述两种磷脂酶Ａ＿２抑制剂均能明显改善内毒素所致红细胞膜磷脂降解及脂质过氧化反应的增强，维生素Ｅ则具有明显的抗脂质过氧化作用。提示，由磷脂酶Ａ＿２激活所介导的膜磷脂降解及脂质过氧化在内毒素所致生物膜损伤中具有重要意义。he protective effects of phospholipase A2 inhibitors,chloropromazine and dexamethasone,andantioxidant vitamine E on biomembranes injuries induced by endotoxin adininistration were studiedon wistar male rate. The resulte showed that phospholipase A2 inhibitors significantly prevented themembrane phospholids structure from phospholipase A2 involved degradation and reduced theaccumulation of lipid peroxidation induced by endotoxin administration,and antioxidant vitamine Ehad a powerful effect in the prevention of lipid peroxidation.It is suggested that the activation ofphospholipase A2 and lipid peroxidation may play critical roles in the procese of biomembranesinjuries induced by endotoxin administration.

关 键 词：磷脂酶A2 内毒素生物膜 过氧化脂质 

分 类 号：Q545[生物学—生物化学]