超选择大剂量碘化油栓塞原发巨块型肝癌(附53例分析)  

Superselective transcatheter chemoembolization with large doses iodized oil in the treatment of huge primary hepatic carcinoma (analysis of 53 cases)

作　　者：张学彬[1] 吕维富[1] 张行明[1] 胡曙东[1] 荚伟萍[1] 厉月琴[1] 赵锡军[1] 

机构地区：[1]安徽医科大学附属省立医院放射科,安徽合肥230001

出　　处：《医学影像学杂志》2005年第6期469-473,共5页Journal of Medical Imaging

摘　　要：目的:评价超选择大剂量碘化油栓塞治疗原发性巨块型肝癌的有效性及安全性,并探讨其机制。方法:回顾分析行超选择大剂量碘化油栓塞原发性巨块型肝癌5 3例,碘化油用量15～5 5ml。选取同期行常规剂量碘化油治疗的巨块型肝癌6 0例作为对照,碘化油用量2～15ml。分析两组术前术后病灶大小变化、肝功能变化、并发症、近期有效率及生存率。结果:大剂量组近期有效率明显高于常规剂量组,肝功能指标较常规剂量组增高,并发症发生率与常规剂量组相当。大剂量组1、2、3年生存率分别为:86 .79%、39.6 2 %、2 2 .6 4 % ;而常规剂量组分别为:5 3.33%、16 .6 7%、12 .5 0 %。结论:超选择大剂量碘化油栓塞治疗巨块型原发性肝癌较常规剂量组虽疗效有明显提高,肝功能损害亦同时有所加重,但严重并发症发生率未见增加。Objective:To evaluate the efficacy and safety of superselective transcatheter chemoembolization (ssTACE) with large dose of iodized oil in the treatment of primary hepatic carcinoma (PHC) and to discuss the potential mechanism.Methods:We retrospectively analysed the effective power, survival rate and the changes in diameter and liver function between two groups of patient which were treated during Jan 2000 to Dec 2003. One group(n_1=53) was treated with large dose of iodized oil(15～55ml) and the other(n_2=60) was treated with normal dose(2～15ml).Results:The survival rate in large dose group and in regular dose group was 86.79%,39.62%,22.64% and 53.33%,16.67%,12.50% respectively. The hepatic functional parameter was slightly elevated in large dose group and the incidence of complication was comparative with regular dose group.Conclusion:The curative effect is obviously raised with large dose of iodized oil for treatment of huge PHC and damage to hepatic function is increased at the same time, but severe complication is not increased.

关 键 词：肝脏 癌 放射学 介入性 碘化油 

分 类 号：R322.47[医药卫生—人体解剖和组织胚胎学] R815[医药卫生—基础医学]