氟罗沙星的分光光度法研究及应用  

Spectrophotometric Study on Fleroxacin and Its Application

作　　者：李胜[1] 姚俊学[1] 敖登高娃[1] 

机构地区：[1]内蒙古大学化学化工学院,呼和浩特010021

出　　处：《内蒙古大学学报（自然科学版）》2005年第3期274-276,共3页Journal of Inner Mongolia University：Natural Science Edition

基　　金：内蒙古自然科学基金资助项目(200208020114)

摘　　要：研究了以FeCl3为显色剂,氟罗沙星与Fe( )生成络合物的反应条件.在0.8～1.4mol/L盐酸介质中,氟罗沙星与Fe( )在室温下形成稳定的络合物,其最大吸收波长为402nm,摩尔吸光系数为4.8×103L·mol-1·cm-1,氟罗沙星与Fe( )络合物的组成比为2∶1.线性范围为2～48μg/mL.本方法的相对标准偏差小于2.8%.应用拟定的方法对含氟罗沙星药物的片剂和胶囊进行了含量测定,结果满意.A method for the determination of FLE in the tablets and capsules by spectrophotometry has been developed.It is found that in 0.8～1.4 mol/L HCl medium,Fe(Ⅲ) reacts with fleroxacin to form yellow colored complex with a maxium absorption at 402 nm.The apparent molar absorptivity is 4.8×10~3 L·mol^(-1)·cm^(-1).The molar ratio of Fe(Ⅲ) to fleroxacin in the complex is found to be 1∶2.Beer′s law is obeyed in the concentration range of 2～48 μg/mL for fleroxacin.The method was used for direct determination of fleroxacin in the fleroxacin capsules and tablets,and got satisfactory results.

关 键 词：氟罗沙星 三氯化铁 分光光度法 

分 类 号：O657.32[理学—分析化学]