钙剂对急性DIC形成作用的实验观察  

Effect of Ionized Calcium to Promote Acute Disseminated Intravascular Coagulation in Condition of Microcirculatory Disturbance in Rats

作　　者：李时宜[1] 

机构地区：[1]汕头大学医学院儿科教研组

出　　处：《微循环学杂志》1994年第4期12-14,T001,共4页Chinese Journal of Microcirculation

摘　　要：采用提睾肌微循环监测及血液检查包括血气分析的测定，观察健康雄性大白鼠在微循环障碍情况下，Ｃａ＋＋对急性ＤＩＣ的形成的作用。结果：实验组２０只大鼠（加钙组）造病后有典型的急性ＤＩＣ变化，２０只大鼠于３～２４ｈ内相继死亡，经病理组织学检查，部分大鼠的肺毛细血管和小血管内有白色微血栓。而对照组５只鼠微循环障碍为暂时性的红细胞粘连聚集，５只鼠均存活。提示：在微循环障碍情况下，Ｃａ＋＋可促进急性ＤＩＣ形成，应引起临床工作者警惕。Using the monitoring of microcirculation of the cremaster muscle & laboratory findings on blood containins pH/blood gas analysis on Wistar male rats to oboerve the effect of ionized ealcium on acute DIC, in a condition of microcirculatory disturbence. The results showed that all 20 rats suffered from a type of acute DIC. All 20 rats died within 3-24 hours. On histolosical examination, a few hyaline thrombi were found in the capillaries of the lungs of some rats. In the control group, all 5 rats only showed adherent erythrocytes and aggregation with trancient microcirculatory disturbance. All 5 rats survived. The conclusion from this study warns that if a condition of microcirculatory disturbance exists, that ionized calcium would promote the formation of acute DIC.

关 键 词：钙剂 急性DIC 形成作用 实验观察 凝血因子 急性微循环障碍 

分 类 号：R543[医药卫生—心血管疾病]