盐酸二氢埃托啡与盐酸美沙酮联合用于海洛因依赖者戒毒治疗临床评估性研究  

A CLINICAL STUDY ON THE TREATMENT OF HEROIN ADDICTS BY DIHYDROETORPHINE HYDROCHLORIDE COMBINED WITH METHADONE

作　　者：苏木金[1] 邓忭明[1] 何志奇[1] 王珏[1] 沙丽[1] 

机构地区：[1]解放军广州疗养院,广州510515

出　　处：《中国药物依赖性通报》1994年第2期99-102,112,共5页

摘　　要：本文以盐酸二氢埃托啡注射液静滴3d递减法po盐酸美沙酮4d为一疗程,对海洛因依赖者40例进行戒毒治疗,戒毒成功率为92.5％,脱试率7.5％,并与单药盐酸二氢埃托啡组20例,单药盐酸美沙酮组20例进行比较,结果表明本疗法起效快,控制症状彻底,减药时戒断症状轻微平稳,停药后戒断症状反复较少,病人乐于接受,脱试率低,同时缩短盐酸二氢埃托啡与盐酸美沙酮各自用药时间,避免可能产生的药物依赖现象,是一种比较好的海洛因依赖者戒毒疗法。A study for evaluating the treatment of heroin addicts by dihydroetor-phine hydrochloride (DHE) combined with methadone was undertaken. DHE was administered by iv route at first three days then reducing dosage of methadone was administered by po route for four days. The detoxification rate was 92. 5% . The dropout rate was 7. 5% . It is shown that this method controlled the abstinence syndromes rapidly, completely and steadily and the dropout rate was lower. Meanwhile, it was possible to reduce drug dependence because both DHE and methadone are used in only a short period of time.

关 键 词：盐酸二氢埃托啡 海洛因依赖者 盐酸美沙酮 戒毒治疗 临床评估 联合用 戒断症状 控制症状 依赖现象 用药时间 戒毒疗法 递减法 注射液 停药后 单药 

分 类 号：R971.1[医药卫生—药品] R595.5[医药卫生—药学]