腺样体免疫状况与分泌性中耳炎的相关性研究  

The relationship between adenoids hypertrophy and secretory otitis media

作　　者：尹桂茹[1] 岳卓立[1] 胡建功[2] 赵小明[2] 

机构地区：[1]承德医学院附属医院耳鼻咽喉科,河北承德067000 [2]承德医学院附属医院病理科

出　　处：《临床耳鼻咽喉科杂志》2005年第13期588-589,共2页Journal of Clinical Otorhinolaryngology

摘　　要：目的:探讨腺样体免疫状况与分泌性中耳炎(SOM)的相关性。方法:采用VltrasentitiveTMSP免疫组织化学法检测反复发作的SOM伴腺样体增生者46例(反复发作组)及发作次数≤3次者30例(对照组)腺样体组织中CD45Ro、CD20、PCNA及BCL2的表达。结果:反复发作组腺样体组织中CD45Ro、CD20、PCNA及BCL2的表达明显高于对照组,其差异均有统计学意义(P<0.05或P<0.01)。结论:反复发作的SOM患儿腺样体中淋巴细胞活性增高,处于增殖期细胞增多,致使腺样体增生、肥大,同时局部免疫增强,加重了SOM。因此,对于SOM患儿应及早行腺样体切除术。Objective:To investigate the relationship between immune status of adenoids and secretory otitis media(SOM).Method:All the 76 cases of SOM were divided into 2 groups:recurrent group(46 cases) and control group(30 cases whose occcurence was less than 3 times).The manifestation of CD45RO,CD20,PCNA and BCL-2 in adenoids was detected with ultrasensitive TMS-P immunohistology.Result:The expression of CD44Ro,CD20,PCNA and BCL-2 in recccrrent group was significantly higher than that in control group(P<0.05 or P<0.01).Conclusion:In adenoid tissues of recurrent SOM patients,the activities of lymphaytes and cells in hypertrophic status increase,the adenoids enlarge and local immunity enhances.Therefore,adenoidectomy for SOM patients should be carried out as early as possible.

关 键 词：腺样体 中耳炎 分泌性 抗原 CD45 抗原 CD20 增殖细胞核抗原 BCI 2基因 

分 类 号：R764.21[医药卫生—耳鼻咽喉科]