降植烷诱导的关节炎大鼠血清IL-6的动态变化  

Dynamic Changes of Serum IL-6 Levels in Rat Models with Pristane Induced Arthritis

作　　者：王永庆[1] 史贻芳[1] 李东玥[1] 周强[1] 宿芳[1] 刘艳[2] 姜妙娜[3] 贾玉杰[3] 

机构地区：[1]大连医科大学 [2]大连医科大学附属第一医院儿科 [3]大连医科大学病理生理教研室

出　　处：《放射免疫学杂志》2005年第3期173-175,共3页Journal of Radioimmanology

摘　　要：目的:研究降植烷诱导的关节炎(pristaneinducedarthritis,PIA)大鼠血清白介素-6(IL-6)的动态变化。方法:用pristane免疫大鼠建立PIA动物模型,放射免疫分析检测血清IL-6的水平。结果:大鼠血清IL-6水平在pristane免疫后的1、3、8周增高,与免疫前比较有显著性差异(P<0.01),出现2次高峰分别在1和8周;5周IL-6下降,与1周比较有显著性差异(P<0.01)。结论:IL-6可能有参与了PIA发病、反复和进展。Objective To study the dynamic changes of serum IL-6 levels in rat models with pristane induced arthritis. Methods Rat models of arthritis were prepared with subcutaneous injection of pristane, serum IL-6 levels were determined with RIA in the rat models before pristane injection and 1, 3, 5, 8w later. Results Serum IL-6 levels in the rat models were significantly higher 1, 3, 8 w after pristane injection than those before injection (P<0.01). The levels dropped significantly 5w after injection (vs 1wk P<0.01), but rose again with a second peak at 8w. Conclusion IL-6 possibly participated in the initiation progression and relapse of the pristane induced arthritis in rat models.

关 键 词：血清IL-6 动态变化 降植烷 关节炎大鼠 PRISTANE 显著性差异 大鼠血清 动物模型 分析检测 放射免疫 PIA 白介素 免疫后 水平 

分 类 号：R581.1[医药卫生—内分泌] R743.33[医药卫生—内科学]