血浆脑钠素水平与心衰患者左心功能关系的探讨  

Study on thd Relationship Between Plasma BNP Levels and Left Cardiac Function in Patients with Heart Failure

作　　者：尹欣[1] 吴春旭[2] 徐丹丹[1] 

机构地区：[1]解放军105医院检验科,230031 [2]中国科技大学15系,230026

出　　处：《放射免疫学杂志》2005年第3期191-193,共3页Journal of Radioimmanology

摘　　要：目的:为探讨血浆脑钠素(BNP)水平与心力衰竭患者临床心功能变化之间的关系。方法:本文采用IRMA测定患者血浆BNP水平,同时采用NYHA心功能分级和超声心动图检查评定患者左心功能。结果:随着心功能恶化,血浆BNP水平呈上升趋势。各级心功能间差异均有显著性临床意义(P<0.05)。经抗心衰药物综合治疗后,BNP水平降低(P<0.01)。BNP水平与左心室射血分数(LVEF)、左心室短轴缩短率(D%,D即leftventriclefractionshortening)呈负相关;与左室收缩末内径(LVSd)、左室舒张末内径(LVDd)呈正相关。结论:在患者心力衰竭的进展中其血浆中BNP水平与心衰程度密切相关,测定患者血浆BNP水平是监测心衰程度的有效手段之一。Objective To investigate the relationship between plasma brain natriuretic peptide (BNP) levels and cardiac function in patients with heart failure. Methods Plasma levels of BNP (with IRMA) and left cardiac function parameters (examined with echocardiogram) were obtained in 80 patients with heart failure at admission and repeatedly examined in 43 of them later after 2w treatment as well as in 30 controls. Results The plasma BNP levels increased along with the deterioration of cardiac function, with significant differences among the patients with different cardiac function grades (P<0.01). After 2w treatment, the plasma BNP levels were significantly lower than those before (P<0.01). The plasma levels of BNP were negatively correlated with left ventricular ejection fraction (LVEF) and left ventricle fraction shortening, but positively correlated with left ventricular end-systolic diameter (LVSd) and left ventricular end-diastolic diameter (LVDd). Conclusion Plasma levels of BNP were closely related to the severity of heart failure and could serve as a biochemical marker for assessing the left cardiac function.

关 键 词：血浆脑钠素 功能关系 心衰患者 ventricle 脑钠素(BNP) 超声心动图检查 左心室射血分数 心力衰竭患者 患者血浆 心衰程度 P水平 心功能变化 心功能分级 抗心衰药物 左心室短轴 IRMA 左心功能 NYHA 上升趋势 临床意义 left 

分 类 号：R541.6[医药卫生—心血管疾病] R973[医药卫生—内科学]