TGF-β_1在糖尿病肾病早期诊断中的应用  

Application of Serum TGF-β_1 Determination for Early Diagnosis of Diabetic Nephropathy

作　　者：江中林 姜国良[2] 

机构地区：[1]安徽省红十字铜陵医院检验科,244000 [2]安徽省红十字铜陵医院内分泌科,244000

出　　处：《放射免疫学杂志》2005年第3期195-196,共2页Journal of Radioimmanology

摘　　要：目的:探讨转化生长因子-β1(TGF-β1)在糖尿病早期肾病诊断中的临床应用价值。方法:采用放射免疫分析检测糖尿病患者血清及尿中β2-微球蛋白(β2-m),采用酶联免疫分析(ELISA)法检测糖尿病患者血清中TGF-β1。同时检测尿白蛋白(uAlb)及尿微量蛋白,按尿白蛋白的排泄率分为三组。结果:糖尿病患者TGF-β1、血β2-m、尿β2-m与尿Alb具有很好的正相关性。结论:检测血清TGF-β1、血β2-m、尿β2-m是诊断糖尿病早期肾损害的敏感指标,对糖尿病肾病的早期诊断具有一定的临床应用价值。Objective To investigate the feasibility of obtaining early diagnosis of diabetic nephropathy (DN) with determination of serum transforming growth factor-β_1(TGF-β_1). Methods Serum TGF-β_1 (with ELISA) and β_2-microglobulin (β_2-m, with RIA) levels as well as urinany β_2-m, albumin and mciro-amount of proteins were determined in 35 controls and 84 diabetic patients with different degrees of albuminuria (Group A: urinary albumin excretion UAE<30mg/24h, n=29; Group B: UAE 30~300mg/24h, n=27; Group C: UAE>300mg/24h, n=28). Results The serum TGF-β_1,β_2-m and urinary β_2-m contents were correlated well with UAE in the diabetic patients. Conclusion TGF-β_1 and β_2-m were sensitive markers for early renal function injury in diabetic patients and determination of serum TGF-β_1 levels was clinically useful for diagnosis of early DN.

关 键 词：糖尿病肾病 早期诊断 转化生长因子-β 血清TGF-Β1 临床应用价值 糖尿病患者 糖尿病早期肾病 β2-微球蛋白 血β2-m 尿Β2-M 酶联免疫分析 尿白蛋白 尿微量蛋白 早期肾损害 分析检测 放射免疫 同时检测 尿ALB 敏感指标 

分 类 号：R587.2[医药卫生—内分泌] R575.2[医药卫生—内科学]