大鼠双侧供肾移植模型的建立  

Establishment of the kidney transplantation model in rats:two renal allografts harvested from one donor

作　　者：冯宁翰[1] 钱立新[1] 华立新[1] 郑峻松[2] 宋宁宏[1] 眭元庚[1] 张炜[1] 吴宏飞[1] 

机构地区：[1]南京医科大学第一附属医院泌尿外科肾移植中心,江苏南京210029 [2]第三军医大学西南医院全军烧伤研究所,重庆市器官移植基础研究所,重庆400038

出　　处：《南京医科大学学报（自然科学版）》2005年第8期521-523,543,共4页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金资助项目(30200264);国家自然科学基金资助重大项目(39993430-2)

摘　　要：目的:首创了一种可以同时取供体的双肾作供肾的大鼠肾移植模型。方法:以近交系Brown鄄Norway大鼠和近交系Lewis大鼠作为供、受体,取供体的双肾作为供肾,借助静脉支架管,行供体的静脉与受体肾静脉的端端吻合,肾动脉与腹主动脉行端侧吻合。结果:手术均于60min内完成。所有的受体均存活超过7天,围手术期死亡数为0。结论:首创双侧供肾大鼠肾移植模型是一种节省、可靠、实用的大鼠肾移植模型。Objective: To establish an economical and feasible rat renal trans plantation model. Methods: Inbred Brown-Norway and Lewis mice were used as the d onors and the recipients. Both kidneys were removed from the donors. With the h elp of PTCA tube, an end-to-end anastomosis of vein was operated. Results: All operations were finished within 60 min. No one recipient died during operatio n period. Conclusion: The newly established method is feasible and reliable.

关 键 词：大鼠 肾移植 模型 

分 类 号：R617[医药卫生—外科学]