小剂量红霉素治疗新生儿喂养不耐受  

Feeding intolerancc of new - born treated with Erythromycin in low amount

作　　者：石瑄[1] 魏金铠[1] 王欣[1] 许月红[1] 李小英[1] 

机构地区：[1]河北省职工医学院附属医院,河北保定071000

出　　处：《河北职工医学院学报》2005年第2期13-15,共3页Journal of Hebei Medical College for Continuing Education

摘　　要：　目的探索小剂量红霉素静点治疗新生儿喂养不耐受的疗效。方法选择2002年10月-2003年3月住院新生儿符合新生儿喂养不耐受标准40例,随机分为治疗组、对照组各20例,两组新生儿均给常规综合治疗,治疗组在常规综合治疗基础上加用红霉素静点3-5mg/kg.d,治疗时间3-7d。临床观察每日进奶量、胃潴留、腹胀、体重、大小便情况。结果静点小剂量红霉素后与对照组比较喂奶量增加(12±42ml/kg.d,80±28ml/kgd)、胃潴留减少(2.15±0.86ml/次,6.75±3.14ml/次)、腹胀消失(2.0±1.5d,4.1±1.8d)、体重增加(0.64±0.41kg,0.32±0.25kg)、喂养的耐受时间(1.8±1.2d,3.50±1.7d)明显缩短,两组比较有显著性差异(P<0.01)。结论早期小剂量红霉素静点结合调整胃肠功能药的使用可促进胃肠动力,提高喂养耐受性,减少应用静脉营养,无明显毒副作用,可减少医疗费用,促进患儿健康,值得推广。Objective To study the treating effect of Erythromycin in low amount in the treatment of feeding intolerance of new-born. Methods 40 new-borns with feeding intolerance were treated in our hospital from October, 2002 to March, 2003. The patients were divided into the experimental group and the control group randomly, each group consisted of 20 patients. The patients in the experimental group were treated with routine general therapy combined with Erythromycin(3-5mg/kg) daily for 3-7 days, the conditions of weight, faces,urine, abdominal distension, food retention and the milk feeding state were observed, and the controls were treated with routine general therapy. Results Compared with the controls, the milk feeding amount of the patients in the experimental group increased (120 ± 42ml/kg. d 80 ± 28ml/kg. d), the food retention decreased (2.15± 0. 86ml/time, 6. 75± 3.14ml/ time), the abdominal distension disappeared(2.0± 1. 5d, 4.1±1.8d), the weigh increased (0.64±0.41kg, 0.32±0.25kg), the feeding intolerance shortened significantly (1.8±1.2d, 3.50± 1.7d). There was a significant difference between the experimental group and the controls(P<0.01). Conclusion Erythromycin in low amount through intravenous drip combined with the medicine that could adjust the gastrointestinal function could improve the gastrointestinal function, increase the feeding intolerance, reduce the nutrition of the artery and medical cost, promote the health of the patients, which has no side effects, thus, this therapy is worthy to be applied widely in clinical practice.

关 键 词：新生儿 喂养不耐受 小剂量 红霉素 静脉滴注 胃肠动力 

分 类 号：R722.19[医药卫生—儿科] R174.4[医药卫生—临床医学]