长春瑞宾渗漏后皮下注射解毒剂的实验研究  

Experimental research on hypodermic antidote after leak of vinorelbine

作　　者：张兰凤[1] 孟凡迅[2] 张金业[1] 段文娟[2] 李海燕[2] 徐芬芬[1] 仇芳芳[1] 

机构地区：[1]南通市肿瘤医院,226361 [2]南通大学启秀校区生物技术部

出　　处：《中国实用护理杂志》2005年第7期3-5,共3页Chinese Journal of Practical Nursing

基　　金：江苏省南通市卫生局2003立项课题(编号:W0303)

摘　　要：目的对长春瑞宾渗漏后常用的数种局部解毒药物进行药效优选。方法建立长春瑞宾外渗损伤的SD大鼠实验模型,分别皮下注射盐酸山莨菪碱等临床常用的数种治疗长春瑞宾外渗损伤的药物,对渗漏部位的皮下硬结、红斑、溃疡和大鼠的功能形态变化以及损伤修复时程进行对比观察,并设立生理盐水皮下注射实验对照。结果采用盐酸山莨菪碱等药物治疗的解毒效果显著。结论治疗长春瑞宾血管外渗损伤可首选盐酸山莨菪碱作为解毒剂。Objective To probe the drug potency of several local antidote after leak of vinorelbine. Methods To build the rat experimental model for leak of vinorelbine, each of them was injected endermiclly anisodamine hydrochloride and some clinical conventional drugs etc. We also established a control group, which were treated with 0.9% sodium chloride, observed and compared the repairing period for subcutaneous induration, erythema, ulcer and rat's change of function and appearance. Result Anisodamine hydrochloride has significant effect to cure leak of vinorelbine. Conclusion We regarded anisodamine hydrochloride as the first choise drug to cure leak of vinorelbine.

关 键 词：长春瑞宾 皮下注射 解毒剂 实验研究 渗漏 盐酸山莨菪碱 大鼠实验模型 血管外渗损伤 解毒药物 方法建立 临床常用 皮下硬结 对比观察 损伤修复 形态变化 实验对照 生理盐水 效果显著 药物治疗 

分 类 号：R96[医药卫生—药理学]