胆囊结石病的胆囊粘膜病变研究  

THE STUDY OF GALLBLADDER MUCOSA LESIONS IN CHOLELITHIASIS

作　　者：高维实[1] 李敏[1] 李利宁[1] 郑建华[1] 孙慧宽[2] 

机构地区：[1]内蒙古自治区医院普外科,010017 [2]内蒙古医学院病理解剖教研室

出　　处：《中国普通外科杂志》1996年第2期80-82,共3页China Journal of General Surgery

摘　　要：作者应用组织化学和免疫组织化学技术,对95例连续收集的胆石病胆囊标本进行研究。结果发现,59例(62.1%)粘膜上皮出现化生,26例(27.4%)出现异型增生,化生和异型增生的发生率均随年龄增加而增高,50岁以上患者二者的发生率显著增高。作者认为,结石是引起胆囊粘膜上皮化生和异型增生的主要原因,50岁以上胆石病患者发生胆囊癌的危险性明显增高。We studied 95 cases of gallbladder stones by means of histochemical and immunohistoche-mical methods. We found that 59 cases (62.1%) presented metaplasia and 26 cases (27.4%) presented dysplasia on gallbladder mucosa. The incidence of metaplasia and dysplasia increased with the age of the patient and especially when patient's age was over 50 years old. This study suggested that metaplasia and dysplasia of gallbladder epithelium were significantly related to gallstones, and the risk of gallbladder canceration was increased obviously when the age of patient with gall stone was over 50 years old.

关 键 词：胆囊粘膜 胆囊结石病 病变研究 免疫组织化学技术 50岁以上 异型增生 粘膜上皮 上皮化生 胆石病 发生率 增高 胆囊癌 作者 出现 患者 

分 类 号：R657.42[医药卫生—外科学] R575.62[医药卫生—临床医学]