大白鼠固定比率连续自身给药实验动物模型的建立  

A CONTINUOUS SELF-ADMINISTRATION MODEL UNDER FIXED RATIO IN RATS

作　　者：王卫平[1] 谢潞[1] 郑继旺[1] 蔡志基[1] 

机构地区：[1]北京医科大学中国药物依赖性研究所,北京100083

出　　处：《中国药物依赖性通报》1994年第4期214-217,共4页

摘　　要：本实验采用固定比率为1:1的4h连续自身给药实验模型,药物是经典的具有较强精神依赖性的盐酸吗啡。在低于形成身体依赖性的阈下剂量,大白鼠经过一定的训练后能形成主动的觅药行为。改变每次响应注射剂量后,大白鼠均能通过调整踏板次数来控制药物的摄入量,组间t检验踏板次数有显著性差异,而日剂量无明显差异,说明精神依赖性已经形成。大白鼠自身给药实验形成稳定模型的周期短,且药物进入大鼠静脉时不延期、不打扰动物,给药的剂量准确,影响因素少,所得到的实验结果稳定可靠。The experiment was carried out with a 4 - hour continuous intravenous self-administration of morphine under fixed ratio 1: 1 (FR=1). Through several days' training, the rats learned to press lever and drug - seeking behavior was established even under the sub-threshold dose of physical dependence. The rats could maintain self - administration by increasing the response rate (P<0. 05) if the dose was reduced, or decreasing the response rate if the dose was increased, (P<0. 05). However, the total daily dose remained constant. The advantages of the experiment are as follows: 1. the formation of the model needs less time; 2. drug gets into the vein of rats without delay; 3. the rats will not be disturbed; 4. the dose taken is precise; 5. the result is reliable.

关 键 词：自身给药 固定比率 大白鼠 实验动物模型 精神依赖性 身体依赖性 显著性差异 实验模型 盐酸吗啡 阈下剂量 觅药行为 注射剂量 药物 训练后 摄入量 t检验 日剂量 次数 

分 类 号：R971.2[医药卫生—药品] R285.5[医药卫生—药学]